Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Clinical trials of APC in adult sepsis initially showed improved outcome but recent trials showed no benefit in adults or children. 31612119

2019

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE The beneficial cytoprotective effects of APC have been extensively studied and confirmed in a number of preclinical disease and injury models including sepsis, type-1 diabetes and various ischemia/reperfusion diseases. 30974752

2019

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE None of the meta-analyses of recombinant activated protein C showed beneficial effects in sepsis. 31689983

2019

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Activated Protein C (especially in patients with sepsis) or Thrombomodulin are proposed as antithrombotic medications. 31256946

2019

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. 29343482

2018

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Recombinant APC and soluble fragments of TM (sTM) have been tested in settings associated with insufficiency of the endogenous TM/APC pathway, such as sepsis. 27836986

2017

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE These findings suggest that the anti-inflammatory function of APC at therapeutic concentrations may include the inhibition of NETosis in an EPCR-, PAR3-, and Mac-1-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC in disease states including sepsis. 28408624

2017

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression BEFREE In conclusion, proinflammatory conditions of sepsis repress mRNA coding ADAMTS13 and the ameliorating effect by selenite and APC may support the concept for identification of beneficial mechanisms triggered by these drugs at a molecular level. 25860876

2015

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Our data provide a new contextual model of how histones affect aPC generation, and how heparinoid therapy may be beneficial in sepsis. 24177324

2014

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C receptor (EPCR) dependent and likely underlie protective effects of APC in animal models of sepsis, myocardial infarction and ischemic stroke. 25032959

2014

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. 22608565

2012

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Although initial hypotheses focused on antithrombotic and profibrinolytic functions of APC in sepsis, other agents with more potent anticoagulation functions were not effective in treating severe sepsis. 19995397

2010

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Our data in vitro and in vivo support the paradigm that PAR1 contributes to protective effects of APC on vascular barrier integrity in sepsis. 19350118

2009

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation BEFREE Animal studies suggest that aPC variants with near-normal signaling function, but with greatly diminished anticoagulant potential may exhibit a substantially improved risk-to-benefit ratio in sepsis therapy. 19630784

2009

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Furthermore, activated protein C (APC) inhibited LPS-stimulated hBf promoter activity and protein expression in human monocytes suggesting that the beneficial effect of APC therapy in sepsis may in part be due to inhibition of complement induction and/or activation via the alternative pathway. 19279234

2009

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation BEFREE Several other clinical trials evaluating recombinant human APC have been completed, including studies in children and less severely ill adults with sepsis as well as a study in acute lung injury. 19466992

2009

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Wnt5A is critically involved in inflammatory macrophage signaling in sepsis and is a target for antiinflammatory mediators like APC or antagonists like sFRP1. 18174455

2008

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression BEFREE Reduction in host-activated protein C levels and resultant microvascular thrombosis highlight the important functional role of protein C anticoagulant system in the pathogenesis of sepsis and septic shock. 18579691

2008

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Therapeutic CTD_human Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). 17556722

2007

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Therapeutic CTD_human Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. 11820775

2002

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker BEFREE Activated protein C (APC) protects against sepsis in animal models and inhibits the lipopolysacharide (LPS)-induced elaboration of proinflammatory cytokines from monocytes. 10930989

2000