Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6. 31678139

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Administration of a specific Nln inhibitor Agaricoglyceride A (AgaA) to mice after stroke in a middle cerebral artery occlusion model, dose-dependently aggravated injury measured by increased infarct and edema volumes, blood-brain barrier disruption, increased levels of interleukin 6 and monocyte chemoattractant protein-1, neurological and motor deficit 24 h after stroke. 31486527

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. 30934019

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Patients in the stroke group had higher levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) (391 pg/ml (107-1249) vs 109 (46-236); p = 0.003), interleukin 6 (2.6 pg/ml (0.8-8.1) vs 0.7 (0.4-1.2) p = 0.002) and asymmetric dimethylarginine (ADMA) (0.44 μmol/L (0.39-0.55) vs 0.36 (0.32-0.4); p = 0.0002) than the control group. 31260841

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE In conclusion, IL-6 released after stroke, which is enhanced by wt-tPA through activation of NMDA-Rs and upregulation of ET-1 and JNK, impairs cerebrovascular autoregulation and increases histopathology. 29476447

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Mediation analyses showed that IL-6 mediated the black-white disparity in stroke risk, but mediation was via IL-6 associations with stroke risk factors. 31004072

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE The astrocytic IL-6 was essential to the promoting effects of hyperforin on the neural precursor cells proliferation, neuronal differentiation, angiogenesis, and functional recovery after stroke. 31133816

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE The strongest association occurred between IL-1α, IL-6 and recurrent stroke, other vascular events and death. 30844663

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Factors with an independent influence on the neurological status on the first day of stroke were: sex, WBC, total blood platelet (PLT) count, CRP, S100B and IL-6 levels. 31356182

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Female sex, older age, diabetes mellitus, atrial fibrillation, stroke-associated pneumonia (SAP) and higher National Institute of Health Stroke Scale (NIHSS) score as well as lower mHLA-DR levels, higher IL-6 and LBP-levels at day 1 were associated with poor outcome at 3 months in bivariate analysis. 31269910

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE IL-6 was directly related to CHD, CVD and CUORE scores at V1 and with MI and STROKE at V2. 29953477

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE When dividing PAH patients by median IL-6 level, patients with higher IL-6 had significantly worse RV function (fractional area change [FAC] 23 ± 12% vs 38 ± 11%, tricuspid annular plane systolic excursion [TAPSE] 1.3 ± 0.3 cm vs 2.1 ± 0.5 cm), impaired RV-PA coupling (0.6 ± 0.5%/mm Hg vs 0.9 ± 0.5%/mm Hg), higher right atrial pressure (13 ± 7 mm Hg vs 9 ± 5 mm Hg), reduced cardiac index (2.0 ± 0.5 liters/min/m<sup>2</sup> vs 2.8 ± 1.0 liters/min/m<sup>2</sup>) and lower stroke volume (48 ± 20 ml vs 70 ± 28 ml). 28893516

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Unstimulated macrophages isolated from naïve rats only upregulated expression of TNF-α and IL-6 following exposure to serum from Stroke rats. 30290827

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation BEFREE Stroke recurrence rates in patients with different genotypes of IL-6 promoter were evaluated by 1-year follow-up. 29091301

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression BEFREE Although the prognostic value of IL6 is limited for the prediction of CHD events, it may have a role for the prediction of stroke, HF and all-cause death in asymptomatic statin users. 30312930

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE The relationships among leukocyte numbers, cortisol, adrenocorticotropic hormone, interleukin-6, and metanephrines were assessed at 72 hours after stroke. 29097060

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Still, the therapeutic potential of IL-6 after experimental stroke has not yet been investigated in a clinically relevant way. 28587928

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation BEFREE Herein we investigated, for the first time, the association of genetic polymorphisms of IL-6, CDKN2A- CDKN2B and other genes with ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study. 28716248

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE In this large cohort of patients with acute ischemic stroke, IL-6 and NT-proBNP at admission were strong and independent prognostic markers for 90-day all-cause mortality, and provided complementary prognostic information to the routinely used stroke severity score NIHSS. 28348074

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke. 28751018

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE IL-6 was significantly increased in plasma (P=0.04) and CSF (P=0.04) in stroke dogs compared with healthy controls. 28079628

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE By comparing the serum levels of inflammatory biomarkers, it was observed that IL‑6 and B1R levels tended to decline whereas IL‑10 levels increased in stroke patients from <30 days to over 180 days. 28990089

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Integrating IL-6 and Lp-PLA2 into the models can significantly enhance the risk prediction accuracy of primary stroke. 28917588

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation BEFREE Our results indicate that IL-6 promoter -174 polymorphisms may play a role in susceptibility to stroke, but not stroke outcome. 27049557

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker BEFREE Our findings have implications for the use of cancer therapies that target VEGF or IL6 and for understanding abnormal angiogenesis in cancers, chronic inflammatory disease, and stroke. 26081809

2015