|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
Finally, 12 case-control studies were included: 8 analyzing <i>PAI-1</i> polymorphism (600 children with stroke and 2152 controls) and 4-<i>FXIII</i> polymorphism (358 children with stroke and 451 controls).
|
31530188 |
2020 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
BEFREE |
In the multivariate Cox regression analysis adjusted for potential confounders, the independent predictors of stroke or TIA were CLT > 115 minutes (hazard ratio [HR] 7.67, 95% confidence interval [CI] 2.78-21.17; P < 0.0001), PAI-1 (HR 1.16, 95% 1.05-1.28; P = 0.003), and CHA<sub>2</sub>DS<sub>2</sub>-VASc score ≥3 (HR 5.18, 95% 1.76-15.29; P = 0.003).
|
31740169 |
2020 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
BEFREE |
Adult C57Bl/6J mice were subjected to unilateral transient middle cerebral artery occlusion (MCAO) followed by reperfusion for 3, 24, 72, or 120 h. Quantitative PCR revealed that brain mRNA expression levels of the PAS components, and particularly of PAI-1 (237-fold) and PAI-2 (19-fold), peaked at 24 h after stroke.
|
29978354 |
2019 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
BEFREE |
PAI-1 4G/5G polymorphism had no effect on PAI-1 levels and did not influence stroke severity.
|
31637872 |
2019 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
However, association studies have yielded conflicting results regarding the association between PAI-1 polymorphisms and stroke susceptibility.
|
26742513 |
2017 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
BEFREE |
This article reviews contemporary knowledge regarding the complex interplay of obesity, PAI-1 and stroke.
|
28378106 |
2017 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
BEFREE |
The plasminogen activator inhibitor-1 (PAI-1) gene has been found to be associated with the pathogenesis and progression of vascular diseases including stroke.
|
28460568 |
2017 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
The aims of this study are to investigate whether the polymorphisms at the PAI-1 gene are associated with the risk of stroke and to explore the combined effects of PAI-1 variants and combined oral contraceptive (COC) use for stroke risk.
|
25231632 |
2014 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
BEFREE |
Polymorphisms in plasminogen activator inhibitor-1 (PAI-1, SERPINE1) and tissue plasminogen activator (tPA, PLAT), such as PAI-1 (-675 4G/5G deletion/insertion) and tPA (Alu insertion/deletion [I/D]), are associated with strokes, myocardial infarctions, bacterial infections and septic shock severity, and trauma.
|
23570848 |
2013 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study suggest that -7351C/T polymorphism of tPA and 4G/5G polymorphism of PAI-1 are not associated with stroke, while as DD genotype and D allele of tPA gene are important risk factors for ischemic stroke.
|
22240314 |
2012 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
PAI-1 4G/4G genotype is associated with reocclusion rates and poor functional outcome among stroke patients treated with t-PA.
|
20374070 |
2010 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
BEFREE |
Our results demonstrate causal relationships for four of the most robust genes associated with stroke while also showing that PAI-1 4G/5G polymorphism influences cardiovascular risk via a mechanism not simply related to plasma levels of PAI-1 (or tPA) alone.
|
20161734 |
2010 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
Our results demonstrate that A-G-4G PAI-1 gene haplotype is associated with increased risk of small vessel disease stroke, but this study does not support an association of -844 G/A, -675 4G/5G, and HindIII G/C PAI-1 gene polymorphisms with particular etiology of ischemic stroke.
|
19154538 |
2009 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
BEFREE |
Consequently, in this study, we may assert that PAI-1 gene, 4G4G and 5G5G genotypes, PAI-1 activity, and homocysteine level determination are significant criteria for identifying patients who are likely to develop stroke; on the other hand, a direct relation does not exist between gene polymorphism and enzyme activity.
|
18662099 |
2008 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
LHGDN |
Consequently, in this study, we may assert that PAI-1 gene, 4G4G and 5G5G genotypes, PAI-1 activity, and homocysteine level determination are significant criteria for identifying patients who are likely to develop stroke; on the other hand, a direct relation does not exist between gene polymorphism and enzyme activity.
|
18662099 |
2008 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
BEFREE |
In fact, PAI-1 mRNA is up-regulated in mouse brain after stroke.
|
19132224 |
2008 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
She was also homozygous for plasminogen activator inhibitor 1 (PAI-1) 4G/4G, which at present is a controversial stroke risk factor.
|
18827269 |
2008 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
Biomarker |
LHGDN |
Two cousins with neonatal stroke, PAI-1 4G variant and MTHFR A1298C mutation.
|
17641264 |
2007 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
There was evidence of stroke association with the PAI-1 4G/5G locus.
|
17689414 |
2007 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
LHGDN |
Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: a meta-analysis.
|
17581326 |
2007 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the association of PAI-1 and tPA levels with stroke as a function of PAI-1 4G/5G and -844G/A genotypes, as well as the link between these PAI-1 gene variants and stroke risk, in a case-control study of 135 ischemic stroke patient, diagnosed according to clinical and radiologic findings and confirmed by computed tomography scan.
|
17689411 |
2007 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
LHGDN |
There was evidence of stroke association with the PAI-1 4G/5G locus.
|
17689414 |
2007 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
The 4G allele is associated with higher PAI-1 levels, but this study does not support an association of the PAI gene polymorphisms with the risk of either myocardial infarction or stroke.
|
17161063 |
2006 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
GeneticVariation |
BEFREE |
Association between 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene with stroke or encephalopathy after cardiac surgery.
|
16508752 |
2006 |
|
SERPINE1
|
Cerebrovascular accident
|
0.100 |
AlteredExpression |
BEFREE |
Stroke is not so clearly related to hypercholesterolemia and other effects of the 4G/4G genotype (perhaps increased PAI-1 expression) may protect against stroke.
|
16735791 |
2006 |