Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0154251
Disease: Lipid Metabolism Disorders
Lipid Metabolism Disorders 		0.030 Biomarker BEFREE Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are a well-known class of drug with beneficial therapeutic effects in cardiovascular disease and lipid disorders and have potential use against cancer. 30203471

2019
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0154251
Disease: Lipid Metabolism Disorders
Lipid Metabolism Disorders 		0.030 Biomarker BEFREE Statins act by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are an important drug class in the treatment of lipid disorders. 30149418

2018
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0154251
Disease: Lipid Metabolism Disorders
Lipid Metabolism Disorders 		0.030 Biomarker BEFREE The use of statin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for the treatment of dyslipidemia has been associated with dose limiting hepatoxicity, mytotoxicity and tolerability due to myalgias thereby necessitating the synthesis of new drug candidates for the treatment of lipid disorder. 29789011

2018