Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration 		0.330 Biomarker BEFREE CONCLUSIONS The expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration. 28432852

2017
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration 		0.330 Biomarker GENOMICS_ENGLAND Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. 26063658

2015
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration 		0.330 Biomarker BEFREE In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1. 23778376

2013
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration 		0.330 GeneticVariation BEFREE A genetic variation at the HTRA1 gene promoter locus is associated with spinal disc degeneration, suggesting an involvement of the HTRA1 gene in osteoarthritis. 19798546

2010