Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 Biomarker BEFREE C3a and C5a are associated with activation of the NLRP3 inflammasome, implicated in the inflammatory drive in HS. 31688984

2020
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 AlteredExpression BEFREE In skin keratinocytes, lymphocytes, and monocytes, but not in neutrophils, P2X7R and NLRP3 protein expression was significantly increased in HS versus the HC group. 31454821

2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 AlteredExpression BEFREE Furthermore, in HS, there is dysregulated function of other immune players closely associated with macrophage function including: matrix metalloproteases (MMP) 2 and 9 overexpression, toll-like receptor upregulation, impaired Notch signalling, NLRP3 inflammasome upregulation, and dysregulated keratinocyte function. 28656364

2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C0162836
Disease: Hidradenitis Suppurativa
Hidradenitis Suppurativa 		0.330 Biomarker CTD_human Pyoderma gangrenosum and its syndromic forms: evidence for a link with autoinflammation. 27106250

2016