|
POU5F1P4
|
Germ cell tumor
|
0.100 |
AlteredExpression |
BEFREE |
OCT4 is expressed in germ cell tumors but also aberrantly in cancers developing in differentiated tissues.
|
28911263 |
2017 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
AlteredExpression |
BEFREE |
In recent years, many researches have shown that OCT4 is overexpressed in both germ cell tumors and somatic cancers.
|
26152287 |
2015 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
AlteredExpression |
BEFREE |
OCT4 and SALL4 can be used with caution as second-tier normalizers when determining changes in gene expression in germ cells and germ cell tumour components, but the relative transcript abundance appears variable between different germ cell tumour types.
|
24743772 |
2014 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
AlteredExpression |
BEFREE |
Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4.
|
23302226 |
2013 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
AlteredExpression |
BEFREE |
The aberrant expression and distribution of the OCT-4 transcription factor in seminomas may provide some important clues concerning the cell transformation between germ line stem cells (like PGC) and testicular germ cell tumors.
|
17682839 |
2007 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
Moreover, the findings argue against OCT3/4 being a driving oncogenic factor in the pathogenesis of human germ cell tumors.
|
17549357 |
2007 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
Although OCT-4 has been introduced as a molecular marker for germ cell tumors, little is known about its expression in somatic cancers.
|
17205510 |
2007 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
TSPY protein localized with established germ cell tumor markers, such as the placental alkaline phosphatase, c-KIT, and OCT3/4, in the same tumor cells of both gonadoblastoma and adjacent carcinoma in situ, the precursor for germ cell tumors.
|
17349529 |
2007 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
The abundance of factors associated with pluripotency (NANOG and OCT-3/4) and undifferentiated state (AP-2gamma) may explain the remarkable pluripotency of germ cell neoplasms, which are capable of differentiating to various somatic tissue components of teratomas.
|
16540528 |
2006 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
GeneticVariation |
BEFREE |
Recently, major progress has been made in identifying gene-products related to germ cell tumor development (testis-specific protein-Y encoded and octamer binding transcription factor 3/4) and in recognizing early changes of germ cells (maturation delay, preneoplastic lesions, and in situ neoplasia).
|
16735607 |
2006 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
In this issue of Cancer Cell, Gidekel et al. demonstrate that Oct-4, a member of the POU class of homeobox genes, is a critical player in the genesis of testicular germ cell tumors.
|
14667497 |
2003 |
|
POU5F1P4
|
Germ cell tumor
|
0.100 |
Biomarker |
BEFREE |
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
|
12727846 |
2003 |