Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker BEFREE Together, these data emphasize the role of complement (C5a) and C5a receptors (C5aR1, C5aR2), as well as extracellular histones in events that lead to cardiac dysfunction of sepsis (septic cardiomyopathy). 29914696

2018
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker BEFREE MEDI7814 has therapeutic potential for the treatment of acute inflammatory conditions in which both C5a receptors may mediate inflammation, such as sepsis or renal ischemia-reperfusion injury. 28952876

2018
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker BEFREE Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of <i>Escherichia coli</i> sepsis. 28720697

2017
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker BEFREE Complement 5a (C5a) has been implicated in the pathogenesis of sepsis by inducing the functional impairment of neutrophils; however, the utility of C5a receptors (C5aRs; C5aR and C5L2) as biomarkers for the management of sepsis is uncertain. 25726869

2016
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker RGD The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. 18648551

2008
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker RGD Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. 14688199

2004
Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0243026
Disease: Sepsis
Sepsis 		0.250 Biomarker BEFREE Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. 11160252

2001