×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
Together these data identify STAT3 as a key molecule underpinning the sexual dimorphism in medulloblastoma .
31683879 2019
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
The results show that dasatinib exerts synergistic effects with cisplatin in human medulloblastoma cells through the inhibition of STAT3 and Src.
30332965 2019
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
Furthermore, it also upregulated the expression of phosphorylated STAT3 , indicating that the IL‑6/GP130/STAT3 pathway plays a central role in medulloblastoma .
29207075 2018
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
Furthermore, combination therapy with S3-NTDi and cisplatin significantly decreased highly aggressive MYC-amplified MB cell growth and induced apoptosis by downregulating STAT3 regulated proliferation and anti-apoptotic gene expression.
29280516 2018
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
AlteredExpression
BEFREE
In line with these findings we show for MYC-amplified medulloblastoma a profound reduction in activity of the oncogenes STAT3 and AKT.
28159923 2017
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
AlteredExpression
BEFREE
The signal transducers and activators of transcription-3 (STAT3 ) pathway are selectively activated in CD133<sup>+</sup> MBSCs and promote tumorigenesis through regulation of c-MYC, a key genetic driver of Group 3 MB .
27775079 2017
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated.
28035977 2016
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
PosttranslationalModification
BEFREE
LY5 inhibited persistent STAT3 phosphorylation and induced apoptosis in human medulloblastoma cell lines expressing constitutive STAT3 phosphorylation.
25313399 2015
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells.
22206672 2012
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
BEFREE
Our results suggest that LLL12 is a potent STAT3 inhibitor and that it may be a potential therapeutic treatment for medulloblastoma and glioblastoma.
21526200 2011
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
AlteredExpression
BEFREE
However, Bcl-2, a common target of STAT3 and NF-κB signaling, is distinctly up-regulated in resveratrol-treated medulloblastoma cells, indicating potential effects of NF-κB in Bcl-2 expression and anti-medulloblastoma efficiency of resveratrol.
21161674 2011
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
AlteredExpression
BEFREE
Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells.
18592012 2008
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
AlteredExpression
BEFREE
High levels of activated/phosphorylated STAT3 were also present in cultured human malignant glioma and medulloblastoma cells.
18829483 2008
×
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
Adult Medulloblastoma
0.400
Biomarker
CTD_human
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
19001435 2008