Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 Biomarker BEFREE Taken together, our findings indicate that targeting IL-6/Stat3 pathway might be a potentially effective therapeutic strategy for treating endometrial cancer. 30922625

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 Biomarker BEFREE Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation. 30452972

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 GeneticVariation BEFREE PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. 29608257

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 Biomarker BEFREE The relationship between lncRNA PCGEM1 and STAT3 during the occurrence and development of endometrial carcinoma. 30257404

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 PosttranslationalModification BEFREE Furthermore, the present study observed that CYP17 is overexpressed via STAT3 phosphorylation in endometrial cancer cells, which grow at a high concentration of PGE2, resulting in increased androgen secretion. 30214592

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 AlteredExpression BEFREE In Ishikawa (grade 1) endometrial cancer cells subjected to media with low, normal, or high concentrations of glucose, expression of STAT3 and its target proteins was evaluated by real-time quantitative PCR (qPCR). 28114390

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 Biomarker BEFREE Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis. 25954856

2015

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 Biomarker BEFREE IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden. 26130650

2015

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 AlteredExpression BEFREE Moreover, we identified signal transducer and activator of transcription 3 (STAT3) as a direct target of miR-124, and over expression of miR-124 not only induced changes in STAT3 expression but also altered expression of its target genes, cyclin D2 and matrix metalloproteinase 2, in the human endometrial carcinoma cell line HEC-1B. 24287565

2014

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 AlteredExpression BEFREE MUC20 is novel prognostic factor for EC and its overexpression enhances EGF-triggered invasive behavior through activation of EGFR-STAT3 pathway. 23262208

2013

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 AlteredExpression BEFREE Autocrine hGH stimulated Y705 phosphorylation of STAT3 and STAT3-mediated transcriptional activity in a SRC and Janus-2 Kinase dependent manner in human EC cell lines. 20668024

2010

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.100 PosttranslationalModification BEFREE Our results indicated that elevated phosphorylation of Stat3 was detected in cervical and endometrial cancer cell lines. 17311011

2007