Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.050 GeneticVariation BEFREE The expressions of eight circadian clock genes (except PER1) at midnight were significantly downregulated in patients with severe OSA. 31590444

2019
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.050 AlteredExpression BEFREE Interestingly, peak expression of clock genes was significantly lower following obstructive sleep apnea (p < 0.05). 27798273

2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.050 AlteredExpression BEFREE CPAP treatment does not correct substantial changes in expression of core clock genes in OSAS patients. 29164122

2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.050 AlteredExpression BEFREE An abnormal rhythm in the expression of circadian clock genes is observed in OSAS patients, and is also implicated in OSAS-related clinical symptoms. 19616563

2009
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.050 GeneticVariation BEFREE To investigate whether obstructive sleep apnoea syndrome (OSAS) influences clock gene function, the present authors examined Period1 (Per1) mRNA expression in vitro and in vivo. 18321934

2008