×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer .
30535495 2019
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province.
29893307 2018
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Thus, this meta-analysis was conducted to comprehensively evaluate the impact of COX-2 expression on the prognostic value in patients with EC .
28652771 2017
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
In the present study, we demonstrated that celecoxib antagonized oxaliplatin-induced cytotoxicity and apoptosis independent of COX-2 inhibition in human esophageal cancer cells.
26474693 2016
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Furthermore, treatment of siRNA for APE-1 significantly reduced COX-2 expression and VEGF production in MCP-1-stimulated esophageal cancer cell lines.
24284961 2014
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
GeneticVariation
BEFREE
We performed a gene-wide tag SNP-based association study to examine the association of SNPs in PTGS2 and PLA2G2A with ESCC in 269 patients and 269 healthy controls from Taihangshan Mountain, Henan and Hebei Provinces, the rural area of China which has the highest incidence of esophageal cancer in the world.
24641411 2014
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
Promising markers that emerged for the prediction of overall survival in esophageal squamous cell cancer included VEGF (18 eligible studies, n=1476, HR=1.85, 95% CI, 1.55-2.21), cyclin D1 (12 eligible studies, n=1476, HR=1.82, 95% CI, 1.50-2.20), Ki-67 (3 eligible studies, n=308, HR=1.11, 95% CI, 0.70-1.78) and squamous cell carcinoma antigen (5 eligible studies, n=700, HR=1.28, 95% CI, 0.97-1.69); prognostic markers for esophageal adenocarcinoma included COX-2 (2 eligible studies, n=235, HR=3.06, 95% CI, 2.01-4.65) and HER-2 (3 eligible studies, n=291, HR=2.15, 95% CI, 1.39-3.33); prognostic markers for uncategorized EC s included p21 (9 eligible studies, n=858, HR=1.27, 95% CI, 0.75-2.16), p53 (31 eligible studies, n=2851, HR=1.34, 95% CI, 1.21-1.48), CRP (8 eligible studies, n=1382, HR=2.65, 95% CI, 1.64-4.27) and hemoglobin (5 eligible studies, n=544, HR=0.91, 95% CI, 0.83-1.00).
24206575 2013
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
GeneticVariation
BEFREE
A large number of studies have demonstrated a strong association between COX-2 polymorphisms and EC risk.
21304218 2011
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
The esophageal cancer cell lines (EC9706) that express COX-2 permanently and hepatocellular carcinoma cell lines (SMMC7721) while no expression of COX-2 were studied.
18443952 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
CTD_human
We evaluated the effects of specific COX-2 inhibitors, NS-398 and nimesulide, on cell lines of both histological types of OC .
17707579 2007
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Esophageal tissue with a positive expression of p53 or COX-2 was more likely to develop esophageal cancer .
17650224 2007
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence.17511025 2007
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer .
16322294 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
CTD_human
We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer .
16322294 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Up-regulation of COX-2 mRNA and protein was observed in esophageal cancer cells transfected with heparanase cDNA.
16299228 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
GeneticVariation
BEFREE
These findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer .
16083713 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
The association of several clinicopathological parameters with the immunohistochemical expression of COX-2 was analyzed in paraffin-embedded esophageal cancer specimens.
15978332 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
Expression of cyclooxygenase-2 (COX-2 ) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398.
15151617 2004
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
These results suggest that COX-2 may be an important factor for esophageal cancer and inhibition of COX-2 may be helpful for prevention and possibly treatment of this cancer.
15259059 2004
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
Increased cyclooxygenase-2 (COX-2 ) expression has been observed in both squamous cell carcinoma (SCC) and adenocarcinoma (AC) in Western countries, and COX-2 inhibitors have been considered as potential chemopreventive agents for esophageal cancers .
12893070 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
AlteredExpression
BEFREE
Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells.
11821953 2002
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
BEFREE
NS398 decreased cell viability in 2 cyclo-oxygenase-2-positive (COX-2 (+)) esophageal cancer cell lines but not in a COX-2(-) cell line.
11410869 2001
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Malignant neoplasm of esophagus
0.400
Biomarker
CTD_human
Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells.
11059772 2000