×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
EGFR inhibitors including both monoclonal antibodies (cetuximab and panitumumab) and tyrosine kinase inhibitors (erlotinib, gefitinib and dasatinib) have been used in clinical trials for the treatment of advanced cSCC , achieving only partial clinical benefit.31747091 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
In the absence of prospective randomized phase 3 trials to evaluate and compare the efficacy and safety of chemotherapeutics, epidermal growth factor receptor (EGFR ) inhibitors and anti-PD-1 antibodies, no final recommendation for systemic therapy can be given for patients with locally advanced or metastatic cSCC .
31833610 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
Treatment for metastatic cSCC was poorly characterized and restricted to the use of chemotherapy and epidermal growth factor receptor inhibitors.
31833609 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
Other treatments, such as epidermal growth factor receptor inhibitors have also been used in the treatment of cSCC with moderate success.
31394558 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
Epidermal growth factor receptor (EGFR ) inhibitors and, more recently, immune checkpoint blockers (ICBs) showed activity in R/M sSCC .31112973 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma .
30683916 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
The development of cutaneous squamous cell carcinoma (cSCC ) is associated with activation of the epidermal growth factor receptor (EGFR ).
31289508 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
EGFR inhibition for metastasized cutaneous squamous cell carcinoma in dystrophic epidermolysis bullosa.31796084 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
This was supported by the high expression of EGFR in CSCC clinical samples.
31638204 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
This study aimed to explore the role of LINC00520 in the development of cSCC via EGFR and phosphoinositide 3-kinase-protein kinase B (PI3K/Akt) signaling pathways.
30707166 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
We conducted a phase 2 trial to determine the response rate to therapy with erlotinib, an EGFR tyrosine kinase inhibitor, in patients with locoregionally recurrent or metastatic CSCC that was not amenable to curative treatment (NCT01198028).
29579331 2018
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
Chronic sun exposure-related fusion oncogenes EGFR -PPARGC1A in cutaneous squamous cell carcinoma .
28978917 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
Epidermal growth factor receptor (EGFR ) activation has been investigated to be associated with the development of cSCC .28243326 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
To evaluate the role of EGFR as a prognostic factor in CSCC .
27510450 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
AKA showed EGFR and MYC anomalies at an incidence intermediate between CKA and SCC .
23521519 2013
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
This action of T-cad in SCC may serve as a paradigm explaining other malignancies displaying concomitant T-cad loss and enhanced EGFR activity.
22592160 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
Biomarker
BEFREE
In view of the 18% complete response rate we observed, EGFR tyrosine kinase inhibitors should be further explored in the treatment of aggressive CSCC .
22261807 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
GeneticVariation
BEFREE
While in other tumors, especially lung cancer and glioblastoma, the EGFR mutations are frequent genetic events, it is unknown whether EGFR is mutated or amplified in SCC of the skin and what would be its pathogenic role in this malignancy and its precursors.
21531084 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
14708611 2003
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of skin
0.100
AlteredExpression
BEFREE
Our findings suggest that the clone with EGFR expression might selectively metastasize in some cutaneous SCC s.
11385224 2001