Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE The TOX3 gene plays a key role during the onset of breast cancer, and reproductive factors such as abortion are risk factors for breast cancer. 31454102

2019

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE TOX3-rs3803662 SNP was associated with breast cancer risk in our study (T vs. C allele contrast model: OR 1.36, 95% CI 1.12-1.64, P<sub>value</sub> = 0.002; TT vs. CT + TT dominant model: OR 0.67, 95% CI 0.51-0.87, P<sub>value</sub> = 0.003; TT vs. CT + CC recessive model: OR 1.54, 95% CI 1.02-2.30, P<sub>vlue</sub> = 0.036). 30515698

2019

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE ER-TOX3/TNRC9 is the best possible pathway involved in the pathogenesis of breast cancer. 31317673

2019

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. 31338012

2019

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE However, African-Americans with TOX3 rs3803662 polymorphism showed decreased breast cancer risk (OR = 0.95; 95% CI: 0.86-1.04; P = 0.28), although the result was not significant. 29578175

2018

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE This study aims to assess the association between single nucleotide polymorphisms (SNPs) of LOC643714 (rs12922061) and TOX3 (rs3803662) and breast cancer, as well as the clinical characteristics of tumors. 29683073

2018

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE This study is the first to provide evidence that genetic variation in MMP9, TOX3, and DAPK1 genes contribute to the development of breast cancer in the Jordanian population. 28272917

2017

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> . 28757652

2017

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE The aim of the present study was to estimate the heritability (h<sup>2</sup>) of breast cancer susceptibility through the analysis of 6 single nucleotide polymorphisms (SNPs), nuclear mitotic apparatus protein 1, cyclin D1, cytochrome C oxidase copper chaperone, fibroblast growth factor receptor 2, TOX high mobility group box family member 3 and solute carrier family 4 member 7. 28943953

2017

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Many of the known breast cancer risk variants were associated with young-onset breast cancer, with evidence that TOX3, ESR1, FGFR2, and RAD51B are important for young-onset disease. 27848153

2017

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE In the study, to test our hypothesis that the previously identified breast cancer risk-associated genetic polymorphisms at the TOX3/LOC643714 locus might contribute to lung cancer risk, 16 SNPs at the TOX3/LOC643714 locus were evaluated in a Han Chinese population based on a case-control study. 27486757

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE To examine molecular mechanisms of TOX3 regulation in breast cancer, we investigated both genetic and epigenetic factors using cell lines and datasets derived from primary breast tumors available through The Cancer Genome Atlas (TCGA). 27806084

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE A comprehensive search was performed to identify all suitable studies involving the TNRC9 rs3803662 polymorphism and BC risk. 27525937

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE The results of the present study suggest that variants of FGFR2 and TNRC9 may contribute to the genetic susceptibility of BC in Pakistani women. 27572905

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer. 26803517

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk. 26911390

2016

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE Here we analyzed TOX3 expression in murine and human mammary glands and in molecular subtypes of breast cancer, and assessed its ability to alter the biology of breast cancer cells. 25632947

2015

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE ORs with 95% CI were used to assess the strength of association between TOX3 polymorphisms and breast cancer risk in fixed or random effect model. 26239137

2015

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Genome-wide association study of susceptibility loci for breast cancer in Sardinian population. 25956309

2015

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Twenty of these regions contained defined genes, including one already associated with breast cancer risk: TOX3. 25956309

2015

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662. 25611573

2015

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE SNPs in the fibroblast growth factor receptor 2 gene (FGFR2) and the TOC high mobility group box family member 3 gene (TOX3) were strongly associated with breast cancer in both races. 24218030

2014

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. 24446301

2014

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042 alleles for BC risk. 24532140

2014

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China. 24481062

2014