Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 AlteredExpression BEFREE In addition, patients with high Ki-67 expression had a worse clinical outcome, including poor tumor differentiation (P=0.001), increased positive lymph node metastasis (P=0.006) and increased worst pattern of invasion type (P<0.0001). 30655856

2019
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 AlteredExpression BEFREE The combined ORs showed that Ki-67/MKI67 expression was related to TNM stage (stage III/IV <i>versus</i> stage I/II: OR=1.93, 95% CI=1.34-2.78, <i>P</i><0.0001), tumor differentiation (poor <i>versus</i> well/moderate: OR=1.94, 95% CI=1.32-2.85, <i>P</i>=0.001), lymph node metastasis (yes <i>versus</i> no: OR=1.67, 95% CI=1.23-2.25, <i>P</i>=0.001), distant metastasis (yes <i>versus</i> no: OR=1.67, 95% CI=1.24-2.26, <i>P</i>=0.001) and tumor invasion depth (T3/T4 <i>versus</i> T<sub>is</sub>/T1/T2: OR=1.98, 95% CI=1.60-2.44, <i>P</i><0.0001). 31632479

2019
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 AlteredExpression BEFREE Finally, we discovered that Notch expression was well correlated with MIB-1 index and lymph node metastases. 27595504

2017
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 Biomarker BEFREE Our results showed that there were statistical associations between Ki-67/MIB-1 and age (odds ratio [OR] =1.71, 95% CI: 1.14-2.57, <i>P</i>=0.010), tumor size (OR =1.86, 95% CI: 1.17-2.96, <i>P</i>=0.008), lymph node metastasis (OR =2.49, 95% CI: 1.42-4.39, <i>P</i>=0.002), metastasis status (OR =6.96, 95% CI: 2.46-19.69, <i>P</i><0.001), tumor node metastasis stage (OR =6.56, 95% CI: 3.80-11.34, <i>P</i><0.001) and extrathyroid extension (OR =1.91, 95% CI: 1.27-2.87, <i>P</i>=0.002). 28740401

2017
Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 Biomarker BEFREE MIB-1 and AgNOR were closely associated with lymph node metastasis (P < 0.01). 9428483

1998