Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE The frequency of genomic alterations seen in SBA demonstrated distinct differences in comparison with either colorectal cancer (APC: 26.8% [85 of 317] vs 75.9% [4823 of 6353], P < .001; and CDKN2A: 14.5% [46 of 317] vs 2.6% [165 of 6353], P < .001) or gastric carcinoma (KRAS: 53.6% [170 of 317] vs 14.2% [126 of 889], P < .001; APC: 26.8% [85 of 317] vs 7.8% [69 of 889], P < .001; and SMAD4: 17.4% [55 of 317] vs 5.2% [46 of 889], P < .001). 28617917

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression BEFREE Relative expression of SNHG7 is upregulated in gastric cancer tissues and cells, and partially contributes to the development and progression of gastric cancer through regulation of p15 and p16 expressions. 29131253

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. 25890171

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression BEFREE The Aζ value of the receiver-operator characteristic curve for methylated p16 was 0.899 for serum and PPWs, compared to that in GC tissues. 24817951

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE The relationship between P16 gene promoter methylation and gastric cancer: a meta-analysis based on Chinese patients. 25693938

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE However, there were no correlations of p16 promoter methylation with the TNM stage and Helicobacter pylori (HP) infection of GC (Tumor size: OR = 0.76, 95% CI: 0.14-4.07, P = 0.746; HP infection: OR = 1.31, 95% CI: 0.75-2.27, P = 0.342; respectively). 24610350

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE On the other hand, the observed pattern of p16 (INK4A) hypermethylation suggests that this event is a good marker for the gastric cancer pathway in the Pará state population. 23504555

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). 23201008

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression BEFREE Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer. 23175521

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE In addition, p16 methylation in chronic gastritis lesions significantly correlated with H. pylori infection; however, such correlation was not observed in GC specimens. 22558275

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC). 22228973

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression BEFREE Our results demonstrate that STAT3, but not STAT5, is involved in GC cell growth and cell cycle progression through regulation of gene expression, such as Bcl-2, p16(ink4a) and p21(waf1/cip1). 22328012

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. 21849808

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer. 20683001

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. 20637757

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer. 19034663

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. 18622497

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE The methylation level of the p16 gene was also associated with the presence of intestinal-type gastric cancer (p = 0.017). 17438355

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE In nonneoplastic mucosa, p14, p16 and p73 methylation occurred in both EBV-associated (8/33, 6/34 and 3/38, respectively) and EBV-negative GC (6/23, 4/35, and 1/35). p73 methylation was observed in the mucosa without H. pylori infection in all 4 samples. 17058198

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE The present study demonstrated for the first time that gastric cancer patients with p16INK4a methylation specifically benefit from 5-FU-based adjuvant chemotherapy. 18008030

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 PosttranslationalModification BEFREE Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. 17139167

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE But five cases in the 25 freshly resected primary GCs displayed deletion in exon 2 of p16 gene. 15818729

2005