Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.120 GeneticVariation BEFREE Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP. 31663982

2020
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.120 GeneticVariation BEFREE Our study suggests lack of association between DNA polymorphisms rs2236479 of COL18A1 and rs2862296 of LOXL-4 with advanced POP in this population. 29532123

2018
Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.120 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 57623
Gene Symbol: ZFAT
ZFAT
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.110 GeneticVariation BEFREE ESR1 rs17847075 genotype AG in the dominant model (P = 0.008) or heterozygous model (P = 0.045), ESR1 rs2234693 genotype TC in the dominant model (P = 0.008) or heterozygous model (P = 0.028), and ZFAT rs1036819 genotype CC and allele C in the recessive model (P = 0.042) were significantly associated with POP risk in Xinjiang woman. 31270553

2020
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.110 GeneticVariation BEFREE In race-specific analysis of grade 0 vs 2-3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62-2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96-4.48, p = 2.6x10-7) were associated with POP in HPs. 26545240

2015
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.110 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 57623
Gene Symbol: ZFAT
ZFAT
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.110 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 107987106
Gene Symbol: CT70
CT70
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 9626
Gene Symbol: GUCA1C
GUCA1C
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 114827
Gene Symbol: FHAD1
FHAD1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 79104
Gene Symbol: MEG8
MEG8
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 1428
Gene Symbol: CRYM
CRYM
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 27067
Gene Symbol: STAU2
STAU2
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 1804
Gene Symbol: DPP6
DPP6
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 5789
Gene Symbol: PTPRD
PTPRD
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 257629
Gene Symbol: ANKS4B
ANKS4B
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASCAT Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. 26545240

2015
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 100505875
Gene Symbol: LINC01088
LINC01088
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 791114
Gene Symbol: PWRN1
PWRN1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 594840
Gene Symbol: ZFAT-AS1
ZFAT-AS1
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.100 GeneticVariation GWASDB Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis. 22105264

2011
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.070 AlteredExpression BEFREE Gene levels of fibulin-5 and ITGβ1 in uterosacral ligaments increased with severity of POP in women with cervical elongation, while no correlation was observed in women with a normal cervix. 29600404

2019
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.070 GeneticVariation BEFREE Loss of the elastogenic organizer, fibulin-5 (FBLN5), leads to pelvic organ prolapse in mice. 31451729

2019
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.070 AlteredExpression BEFREE Real-Time PCR results showed a significant upregulation for extracellular matrix protein 1 (ECM1) and integrin beta 3 (ITGB3) and a significant downregulation for FBLN5 in POP group. 29729708

2018
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.070 Biomarker BEFREE Hence, we hypothesized that prolonged release of fibulin-5 may delay progression of POP. 29073153

2017
Entrez Id: 10516
Gene Symbol: FBLN5
FBLN5
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse 		0.070 GeneticVariation BEFREE Current data provide, for the first time, strong evidence that common SNPs of the FBLN5 gene are associated with POP especially after pelvic floor injury. 24917111

2014