However, rs4929984 is significantly associated with the diastolic blood pressure level of IS patients (additive model: P<sub>adj</sub> = 0.007; dominant model: P<sub>adj</sub> = 0.013), whereas rs217727 is associated with international normalized ratio (additive model: P<sub>adj</sub> = 0.019; recessive model: P<sub>adj</sub> = 0.004), prothrombin time activity level (additive model: P<sub>adj</sub> = 0.026; recessive model: P<sub>adj</sub> = 0.004), and homocysteine level (recessive model: P<sub>adj</sub> = 0.048) in patients with IS.
Conclusions Inherited thrombophilias (factor V Leiden, prothrombinG20210A mutation, protein C deficiency, and protein S deficiency) are associated with an increased risk of arterial ischemic stroke in adults.
In contrast, prothrombin-20210-mutations were different playing a significant role in the pathogenesis of cerebral sinus vein thrombosis, but not in arterial ischemic stroke.
Association Between the 20210G>A Prothrombin Gene Polymorphism and Arterial Ischemic Stroke in Children and Young Adults-Two Meta-analyses of 3586 Cases and 6440 Control Subjects in Total.
To address this issue, we examined the association between prothrombinG20210A and ischemic stroke in a white case-control population and additionally performed a meta-analysis.
Pooled ORs for CVT risk in adults for factor V Leiden and prothrombin were significantly greater when compared against childhood CVT and adult arterial ischemic stroke.
We reviewed the currently available data on the relationship between various inherited and acquired coagulation abnormalities (factor V Leiden and prothrombinG20210A mutations, deficiencies of protein C, protein S and anti-thrombin, hyperhomocysteinemia, the antiphospholipid syndrome and increased levels of fibrinogen) and ischemic stroke.
In case-control studies, multifactorially adjusted odds ratios for ProthrombinG20210A heterozygotes versus non-carriers were 2.0(1.1-3.4) for IHD, 2.0(1.0-3.8) for MI, 1.4(0.7-3.1) for ICVD, and 2.1(0.8-5.4) for IS.
This study suggests that the analysis of prothrombin 20210G-->A and factor XIII Val34Leu is not a useful diagnostic procedure in the work-up of ischemic stroke.
The aim of this study was to evaluate the prevalence of factor V Leiden (FVL), prothrombinG20210A, methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations, and angiotensin-converting enzyme (ACE) I/D polymorphism in ischemic stroke (IS) patients.
Some inherited prothrombotic conditions (e.g., Factor V Leiden, G20210Aprothrombin or methylenetetrahydrofolate reductase C677T polymorphism) could also greatly increase the IS risk if present in OC users.
We describe an unusual case of longitudinal myelitis and ischemic stroke in the presence of homozygous prothrombinG20210A, heterozygous MTHFR 677T mutations and the absence of antiphospholipid antibodies in a young woman with SLE.
The effects of oral contraceptives and their interaction with the G1691A polymorphisms of the factor V gene, the G20210A polymorphisms of the prothrombin gene and the C677T polymorphisms of the MTHFR gene on the risk of cerebral ischaemia were determined in a series of 108 consecutive women aged <45 years with ischaemic stroke and 216 controls, in a hospital-based case-control study design.
In the studied sample of adult North Mediterranean population younger than 65 years the prevalences of factor V Leiden and prothrombinG20210A mutations were greater in patients with ischemic stroke than in matched controls.
The role of inherited prothrombotic conditions, including factor V Leiden (FV G1691A), prothrombinG20210A, and the methylenetetrahydrofolate reductase (MTHFR) C677T genotype, in the pathogenesis of ischemic stroke is not well established.
The association between factor V Leiden (FVL) and prothrombinG20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke.
Genetic abnormalities specific to factor V, prothrombin,and homocysteine metabolism increase the risk for myocardial infarction and ischemic stroke, particularly among younger patients and women.
Available evidence indicates that factor V Leiden, prothrombin 20210A, and lipoprotein (a) are all important in the pathogenesis of arterial ischemic stroke in older children, but the role of other plasma-phase risk factors remains uncertain.
We determined the presence of the prothrombin mutation and examined its influence on carotid and femoral artery intima-media thickness (IMT) and the occurrence of new ischemic events during follow-up in 277 patients with clinically manifest atherosclerotic disease: ischemic stroke, myocardial infarction or peripheral arterial disease.The mean age at entry was 63 years.
In conclusion, our results indicate that FV Leiden mutation, prothrombinG20210A genotype, and homozygosity for the C677T mutation in the MTHFR gene are not associated with an increased risk for ischemic stroke in young adults.