Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE On univariate and multivariate analysis, only ALDH1A1 positivity had a significant effect on OS of HNSCC patients (HR = 2.47 for P = 0.02). 31811857

2020

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE In conclusion, the NLR has power in predicting the expression of ALDH1 in tumors, the circulating level of MDSCs, and the prognosis in HNSCC. 30241364

2018

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE However, MCC950 treatment reduced the expression of NLRP3 inflammasome, CSCs markers BMI1, ALDH1 and CD44 in Tgfbr1/Pten 2cKO mice SCCHN. 28865486

2017

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE This meta-analysis including fourteen studies with altogether 1258 patients updates and summarizes all relevant data on the impact of ALDH1+ CSC on the prognosis of HNSCC and its association with clinicopathological parameters. 29112953

2017

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE Cells with greater expression of CD44 and higher ALDH1 enzymatic activity were FACS sorted from the OM-1 HNSCC cell line. 26399460

2016

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE In this study, we determined that human head and neck squamous cell carcinoma-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) characterized by a high level of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression. 27002147

2016

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE Therefore, we evaluated the microRNA expression profile of ALDH1-high subpopulations in the HNSCC cell lines UTSCC-9 and UTSCC-90. 26323893

2015

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE Stem-like cell population in FA and sporadic HNSCC in human and mouse xenograft tumors were evaluated using ALDH isoform 1 (ALDH1) immunohistochemistry. 25340704

2014

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE In this study, we found that EZH2 and Oct4 are upregulated in HNSCC-derived ALDH1+/CD44+ CSC-like cells. 22361100

2012

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE In this study, we determined that human HNSCC-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) characterized by high levels of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression. 22847005

2012

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE Recent data support the role of ALDH1(+) CD44(+) CSC in HNSCC, since the implantation of a few ALDH1(+) CD44(+) cells consistently gives rise to tumors that can be serially passaged in vivo. 21850700

2012

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE The expression levels of miR200c were significantly down-regulated while BMI1 was increased in HNSCC-ALDH1(+) /CD44(+) compared to the other subsets of HNSCC cells. 21294122

2011

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 Biomarker BEFREE In summary, it is likely that ALDH1 is a specific marker for the cancer stem-like cells of HNSCC. 19450560

2009

Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression BEFREE SCCHN cell lines overexpressing ALDH1 had high enzymatic activity. 17974998

2007