Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4261
Gene Symbol: CIITA
CIITA
Mediastinal (Thymic) Large B-Cell Lymphoma
0.030 Biomarker BEFREE We identified highly recurrent oncogenic mutations in the Janus kinase-signal transducer and activator of transcription and nuclear factor κB pathways, and provide additional evidence of the importance of immune evasion in PMBL (<i>CIITA, CD58, B2M, CD274,</i> and <i>PDCD1LG2</i>). 31292115

2019

Entrez Id: 4261
Gene Symbol: CIITA
CIITA
Mediastinal (Thymic) Large B-Cell Lymphoma
0.030 AlteredExpression BEFREE In summary, we establish CIITA alterations as a common mechanism of immune escape through reduction of MHC class II expression in PMBCL, with potential implications for future treatments targeting microenvironment-related biology. 26549456

2015

Entrez Id: 4261
Gene Symbol: CIITA
CIITA
Mediastinal (Thymic) Large B-Cell Lymphoma
0.030 GeneticVariation BEFREE Genetic alterations of CIITA and PDL1/2 were detected in 26% and 40% of cases, respectively, including 1 G-PMBL-NM case with gain of PDL1/2. 26135560

2015