Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. 18055465

2008

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN The MET oncogene drives a genetic programme linking cancer to haemostasis. 15772665

2005

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. 15557554

2004

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. 10433944

1999

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. 9140397

1997

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN Activating mutations for the met tyrosine kinase receptor in human cancer. 9326629

1997

Entrez Id: 4233
Gene Symbol: MET
MET
Papillary renal cell carcinoma, sporadic
0.300 Biomarker CLINGEN The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. 1917129

1991

Entrez Id: 369
Gene Symbol: ARAF
ARAF
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 6009
Gene Symbol: RHEB
RHEB
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 55294
Gene Symbol: FBXW7
FBXW7
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Papillary renal cell carcinoma, sporadic
0.100 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

Entrez Id: 997
Gene Symbol: CDC34
CDC34
Papillary renal cell carcinoma, sporadic
0.010 AlteredExpression BEFREE We show that the expression of E2-EPF ubiquitin carrier protein, which targets the principal negative regulator of hypoxia-inducible factor (HIF), von Hippel-Lindau protein, for proteasome-dependent degradation, is markedly elevated in the majority of PRCC tumors exhibiting increased HIF1α expression, and is associated with poor prognosis. 21281817

2011

Entrez Id: 27338
Gene Symbol: UBE2S
UBE2S
Papillary renal cell carcinoma, sporadic
0.010 AlteredExpression BEFREE These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC. 21281817

2011

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
Papillary renal cell carcinoma, sporadic
0.010 Biomarker BEFREE These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC. 21281817

2011

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
Papillary renal cell carcinoma, sporadic
0.010 Biomarker BEFREE These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1-mediated regulation of E2-EPF in PRCC. 21281817

2011

Entrez Id: 3093
Gene Symbol: UBE2K
UBE2K
Papillary renal cell carcinoma, sporadic
0.010 AlteredExpression BEFREE We show that the expression of E2-EPF ubiquitin carrier protein, which targets the principal negative regulator of hypoxia-inducible factor (HIF), von Hippel-Lindau protein, for proteasome-dependent degradation, is markedly elevated in the majority of PRCC tumors exhibiting increased HIF1α expression, and is associated with poor prognosis. 21281817

2011