Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation BEFREE Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. 27905104

2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation BEFREE DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR. 19240236

2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN One-carbon metabolism-related gene polymorphisms and risk of breast cancer. 18174236

2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. 18842997

2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. 18095031

2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN GSTP1 and MTHFR polymorphisms are related with toxicity in breast cancer adjuvant anthracycline-based treatment. 17584018

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies. 17476281

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan. 17595805

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis. 17260091

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers. 17151928

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. 16134079

2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer. 17119067

2006
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. 16777985

2006
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. 16777985

2006
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population. 16097444

2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer Study. 15868433

2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. 15510613

2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in the MTHFR gene are associated with breast cancer. 15004488

2004