Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 GeneticVariation BEFREE Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3) from proinsulin and proglucagon, are associated with type 2 diabetes (T2DM) and coronary artery disease (CAD). 24489861

2014
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 GeneticVariation BEFREE A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. 21873549

2011
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 AlteredExpression BEFREE Increased fasting insulin and fasting proinsulin levels both were statistically significantly associated with higher odds of being in either the premature CAD and the non-CAD groups when compared with the reference group in a polychotomous logistic regression model (odds ratio of at least 1.20 for a 20% increase in each beta-cell secretory product in both comparisons, P < 0.05). 8635646

1996