Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE We determined the expression and signaling of NPRs in EAT in the context of CAD progression and their association with brown fat-related genes, such as uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator alpha (PGC1α). 31102956

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE Furthermore, miR-130 negatively correlated with PPAR-γ in both CAD and DM2-CAD group in Pearson's coefficient analysis. 31368668

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE Treatment with the insulin sensitizer PPARγ agonist rosiglitazone in patients with T2DM and CAD is associated with a worsening in aerobic exercise capacity, which seems to be mainly attributable to weight gain and subcutaneous fat mass expansion. 30964707

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE Second, we investigated the potential role of PPARγ activators in the prevention of CAD. 30156736

2018

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease. 29441810

2018

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE Loss of PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α) is implicated in the pathogenesis of CAD. 28533333

2017

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE Logistic regression was used to observe association of SNP within PPARG and CYP1A1 with CAD risk and GMDR model was used to screen the best interaction combinations. 28415751

2017

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 AlteredExpression BEFREE Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR-γ, LP(a), IL-1 and TNF-α in Type 2 Diabetic Patients with Coronary Heart Disease. 28916975

2017

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE We investigated the association of PPAR-γ C1431T-polymorphism with CAD and dyslipidaemia in 787 individuals. 25896411

2015

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 AlteredExpression BEFREE The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ. 25595457

2015

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE Different effects of PPARA, PPARG and ApoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes. 23583468

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis. 23266668

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The effect of PPARG gene polymorphisms on the risk of coronary heart disease: a meta-analysis. 23065280

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The meta-analysis of the association of PPARG P12A, C161T polymorphism and coronary heart disease. 22987045

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population. 22515931

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) is associated with increased risk of coronary artery disease: a meta-analysis. 23300871

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE In conclusion, the PPARγ C1431T polymorphism is associated with decreased risk of CAD in Chinese Han population. 21643757

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The results of the present study demonstrated that possessing the A allele of RAGE -374T/A polymorphism by diabetic CAD patients and possessing the-374T/Ala12 haplotype of RAGE -374T/A and PPAR-γ Pro12 Ala polymorphisms by the patients group were the most important risk factors for CAD. 21861709

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. 21548985

2011

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE PPARgamma C161-->T substitution is associated with a reduced risk of coronary artery disease (CAD). 20334678

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE PPARgamma and LPL have intractable roles in pathways that lead to CAD, but their gene polymorphisms associate differently. 20430250

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 AlteredExpression BEFREE Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease. 21036322

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 AlteredExpression BEFREE It is interesting that monocytes from CAD females expressed significantly higher levels of PPAR-gamma protein compared with male patients (p < 0.05) and showed the lowest basal release of tumor necrosis factor-alpha. 19644041

2009

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker BEFREE These long-term findings in patients with manifest CAD support an important role of PPARgamma in determining vascular risk. 19228871

2009

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation BEFREE The aim was to investigate if the polymorphism PPARgamma2 Pro12Ala, which encodes a less efficient transcription factor, was associated with risk of acute coronary disease and if there were interactions between this polymorphism and factors that modify PPARgamma activity, such as alcohol intake, smoking, and use of non-steroidal anti-inflammatory medicine. 19500413

2009