Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE Heritable variants in the final intron PLPP3 associate with interindividual variability in coronary artery disease risk that may result from disruption of enhancer sequences that normally act in <i>cis</i> to increase expression of the gene. 31362988

2019

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE Pharmacological targeting of bioactive LPP3 substrates, including LPA, may offer an orthogonal approach to lipid-lowering drugs for mitigation of coronary artery disease risk. 31533471

2019

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE Chromatin accessibility quantitative trait locus (caQTL) mapping using HAECs from 56 donors, allelic imbalance assay from 7 donors, and luciferase assays demonstrate that CAD/IS-protective allele at rs17114036 in PLPP3 intron 5 confers increased endothelial enhancer activity. 30429326

2018

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASCAT Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. 30104761

2018

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE In 2011, two genome-wide association studies have identified PLPP3 as a novel locus associated with coronary artery disease susceptibility. 29518748

2018

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778

2018

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females. 28061459

2017

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 Biomarker BEFREE Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. 28291223

2017

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASCAT Association analyses based on false discovery rate implicate new loci for coronary artery disease. 28714975

2017

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASCAT A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 26343387

2015

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE Our results demonstrate a genetic mechanism contributing to CAD risk at the PPAP2B locus and highlight the value of studying epigenetic changes in disease processes involving pathogenic environmental stimuli. 25835000

2015

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 Biomarker BEFREE PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. 26034042

2015

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASDB Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325

2014

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation BEFREE These findings may provide a mechanistic link to explain the association between a PPAP2B polymorphism and coronary artery disease risk. 23104851

2013

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 GeneticVariation GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125

2013

Entrez Id: 8613
Gene Symbol: PLPP3
PLPP3
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.490 Biomarker CTD_human Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. 21378990

2011