Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 AlteredExpression BEFREE In addition, evidence suggested that either miR-22 silencing or FXR knockdown reversed the diminished CCNA2 expression as well as cell proliferation inhibition caused by WA treatment and WA inhibited tumor masses in vivo in a subcutaneous xenograft mouse model of HCC. 27738335

2016
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker CTD_human Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3. 25496033

2015
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker BEFREE Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) is a potential biomarker for hepatitis B Virus associated hepatocellular carcinoma. 24465162

2014
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker CTD_human Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. 23811326

2013
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 AlteredExpression BEFREE In this study, we found that the expression of miR-421 was inversely correlated with FXR protein level in HCC cell lines. 22446874

2012
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker MGD Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. 17283114

2007
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker MGD Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. 17183066

2007
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.530 Biomarker MGD Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. 11030617

2000