×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
BEFREE
Polycystic kidney disease 2 (which encodes TRPP2 ) knockout mice displayed decreased cerebrovascular SOCE-induced contraction.31541223 2019
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
CTD_human
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
30883612 2019
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
BEFREE
We generated the first inducible, smooth muscle-specific knockout mice for a TRP channel, namely for PKD2 (TRPP1 ), to investigate arterial myocyte and blood pressure regulation by this protein.
30511640 2018
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
29899465 2018
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
BEFREE
ADPKD is caused by mutations in the gene encoding either polycystic kidney disease 1 ( PKD1) or polycystic kidney disease 2 ( PKD2 ).
29475398 2018
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
GENOMICS_ENGLAND
Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations.
29321346 2017
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
CTD_human
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.
28887310 2017
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.
27071085 2016
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
The polycystin complex mediates Wnt/Ca(2+) signalling.
27214281 2016
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
CTD_human
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
25877301 2015
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
MGD
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
25574838 2015
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
CTD_human
N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.
24719335 2014
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
BEFREE
Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2 ).
23390131 2013
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
GENOMICS_ENGLAND
Type of PKD1 mutation influences renal outcome in ADPKD.
23431072 2013
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
GENOMICS_ENGLAND
Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to uniparental disomy.
22114106 2012
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD).
21115670 2011
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
MGD
Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease.
20093497 2010
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
GENOMICS_ENGLAND
Perinatal deaths in a family with autosomal dominant polycystic kidney disease and a PKD2 mutation.
18635443 2008
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
MGD
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
16301212 2006
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns.
15772804 2005
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
CTD_human
Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.
15001556 2004
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease.
14993477 2004
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
Biomarker
MGD
Two populations of node monocilia initiate left-right asymmetry in the mouse.
12859898 2003
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease.
12707387 2003
×
Entrez Id: 5311
Gene Symbol: PKD2
PKD2
Polycystic kidney disease, type 2
0.970
GeneticVariation
UNIPROT
Four novel mutations of the PKD2 gene in Czech families with autosomal dominant polycystic kidney disease.
11968093 2002