×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Subgroup analysis based on tumor type showed that the downregulation of miR-145 was associated with unfavorable OS in colorectal cancer (HR = 2.17; 95% CI, 1.52-3.08; <i>P</i> < 0.001), ovarian cancer (HR = 2.15; 95% CI, 1.29-3.59; <i>P</i> = 0.003), gastric cancer (HR = 1.78; 95% CI, 1.35-2.36; <i>P</i> < 0.001), glioma (HR = 1.65; 95% CI, 1.30-2.10; <i>P</i> < 0.001), and osteosarcoma (HR = 2.28; 95% CI, 1.50-3.47; <i>P</i> < 0.001).
30602498 2019
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST.31849487 2019
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
After exposure of colorectal cancer cells with (i) miR-145 and (ii) curcumin-loaded Pr NCs, a strong increase in the intracellular levels of miR-145 , which translated into a decreased cell proliferation rate and migration capacity of the treated cells, was observed.
31326581 2019
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MiR-145 was an unfavorable factor for the prognosis of colorectal cancer .30854930 2019
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer .
29552756 2019
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
microRNA-145 (miR-145 ) has been shown to act as a tumor suppressor in colorectal cancer but its role in the regulation of epithelial-mesenchymal transition (EMT) is unclear.28833449 2018
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
These results suggest that the SNAI1:miR-145 pathway represents a novel therapeutic target in colorectal cancer to overcome RT resistance.
29475734 2018
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145 , a well known tumor suppressor of colorectal cancer .
29416759 2018
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Tumor-suppressive miR-145 co-repressed by TCF4-β-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer .
28921929 2018
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
microRNA-145 regulates tumor suppressor candidate 3 and mitogen-activated protein kinase pathway to inhibit the progression of colorectal cancer .30485502 2018
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Long non-coding RNA SOX21-AS1 sponges miR-145 to promote the tumorigenesis of colorectal cancer by targeting MYO6.
29217166 2017
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
These findings suggest that colorectal cancer cells use miR-145 within EVs to efficiently modulate M2-like macrophage polarization and tumor progression.
28696255 2017
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.28440035 2017
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
miR-145 suppresses colorectal cancer cell migration and invasion by targeting an ETS-related gene.27572146 2016
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer .
27058418 2016
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer .
25896668 2015
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer .
25913620 2015
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1.24642628 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer .
25474488 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
In conclusion, miR-145 might be used as a therapeutic target in the treatment of colorectal cancer patients with BRAF V600E mutation.
24248543 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
These results suggested that the SNAI2:miR145 pathway may represent a novel clinical therapeutic target in colorectal cancer and may serve as a response predictor to chemoradiation therapy.
25249558 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer .
24631504 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Then, we applied it on a gene expression dataset of colorectal cancer clinical patient samples and inferred the perturbed miRNA regulatory networks of colorectal cancer, including several known oncogenic or tumor-suppressive miRNAs, such as miR-17, miR-26 and miR-145 .
25069957 2014
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer .
23121918 2012
×
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer .
18196926 2007