Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.050 Biomarker BEFREE Osteoprotegerin abrogated cortical porosity and bone marrow fibrosis in a mouse model of constitutive activation of the PTH/PTHrP receptor. 19389927

2009
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.050 AlteredExpression BEFREE We conclude that osteosclerosis in IMF is associated with increased endothelial OPG expression without concomitant RANKL downregulation. 15982347

2005
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.050 AlteredExpression BEFREE OPG mRNA expression in fibrotic IMF was correlated with TGF beta-1 mRNA expression in a case-specific manner. 15726648

2005
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.050 Biomarker BEFREE Gene knockout experiments using such animal models have suggested the essential role of hematopoietic cell-derived transforming growth factor beta1 in inducing bone marrow fibrosis and stromal cell-derived osteoprotegerin in promoting osteosclerosis. 16293880

2005
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
CUI: C0001815
Disease: Primary Myelofibrosis
Primary Myelofibrosis 		0.050 Biomarker BEFREE Osteosclerosis in idiopathic myelofibrosis is related to the overproduction of osteoprotegerin (OPG). 15504545

2004