Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.050 GeneticVariation BEFREE ATD-induced agranulocytosis was associated with HLA-B*27:05 (OR 10.97; 95% CI 0.75-159.99), HLA-B*38:02 (OR 19.85; 95% CI 7.94-49.57) and HLA-DRB1*08:03 (OR 5.29; 95% CI 3.44-8.14). 31108563

2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.050 Biomarker BEFREE HLA-B*27:05 (P = 1.10 × 10<sup>-4</sup>), HLA-B*38:02 (P = 2.41 × 10<sup>-4</sup>) and HLA-DRB1*08:03 (P = 1.57 × 10<sup>-3</sup>) were susceptibility HLA variants for ATD-induced agranulocytosis. 28931918

2017
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.050 GeneticVariation BEFREE Genome-wide association studies (GWASs) in ethnic Chinese people in Taiwan and Hong Kong have shown an association between agranulocytosis induced by antithyroid drugs and the HLA alleles HLA-B*38:02 and HLA-DRB1*08:03. 27157822

2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.050 GeneticVariation BEFREE The HLA DRB1*08032 allele was strongly associated with susceptibility to methimazole-induced agranulocytosis, suggesting that cellular autoimmunity may be involved in its development. 8602707

1996
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.050 GeneticVariation BEFREE HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis. 7961560

1994