Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.330 Biomarker BEFREE The reduction of the clozapine nitrenium ion supports association studies showing that NQO2 is a genetic risk factor for clozapine-induced agranulocytosis. 29281794

2018
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.330 Biomarker BEFREE NQO2 1541AA (NRH quinone oxidoreductase 2; protects cells against oxidative metabolites) was present at a higher frequency in agranulocytosis patients compared with control (23% versus 7%, P=0.03), as was ABCB1 (ABC-transporter-B1; drug efflux transporter) 3435TT (32% versus 20%, P=0.05). 27168101

2017
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.330 Biomarker BEFREE Such a reduction in message suggests that the NQO2 gene may be involved in the development of clozapine-induced AGR. 14617031

2003