Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker BEFREE Since the comorbidity between AUD and anxiety is very high and because anxiety is an important factor in ethanol (EtOH) relapse, the aim of the present study was to investigate the role of α-synuclein in moderating EtOH intake, the anxiolytic effects of EtOH, and EtOH withdrawal-induced anxiety and convulsions in mice. 30120834

2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker BEFREE Fifteen candidate gene studies showed hypermethylation of promoter regions of six genes (AVP, DNMT3B, HERP, HTR3A, OPRM1, and SNCA) or hypomethylation of the GDAP1 promoter region in AUD subjects. 27759945

2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 GeneticVariation BEFREE Other studies demonstrated that variability in the SNCA promoter is also associated with alcohol use disorders, but not consistently. 19196539

2009