Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 Biomarker BEFREE Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. 10447460

1999
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 Biomarker BEFREE Using in situ hybridization, we found a selective reduction in mRNA levels for a mitochondrial-encoded subunit, CO II, with preservation of mRNA for a nuclear-encoded subunit, CO IV, in the hippocampal formation of individuals with AD. 8083692

1994
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 GeneticVariation BEFREE It also seems that the C4B2 allele cannot be used as a marker for AD as has been suggested by others. 1940983

1991
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 GeneticVariation BEFREE In contrast to reported findings we failed to find a significant association between C4B2 gene frequency and Alzheimer's dementia. 3350531

1988
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 GeneticVariation BEFREE We were unable to confirm any association between AD and the C4B2 allele. 3502596

1987
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 Biomarker BEFREE Sporadic DAT appears to be associated with the complement allotype C4B2 in the major histocompatibility complex, which is linked very closely to HLA. 3331113

1987
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.070 GeneticVariation BEFREE HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type. 6538270

1984