Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE Cytopenias are an uncommon side effect of low-dose MTX with folic acid supplementation among RA patients. 31504937

2020
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE In contrast to indirect comparison review data, MTX-HCQ seems somewhat more effective after 6 months than MTX monotherapy in early RA patients. 30189019

2019
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE To explore whether tocilizumab + tapering MTX has comparable efficacy and safety vs tocilizumab + stable MTX in adult RA patients with inadequate response to MTX. 29155973

2018
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 AlteredExpression BEFREE To compare 10-year disease outcomes of RA patients who have continuous low disease activity and are on MTX with or without initial combination therapy with infliximab or prednisone and SSZ. 28957556

2017
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE Data analysed were from two randomized phase 3 studies of RA patients (n = 1115) with inadequate response to MTX or TNF inhibitors (TNFi) receiving tofacitinib 5 or 10 mg twice daily, adalimumab (one study only) or placebo, in combination with MTX. 28460083

2017
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 GeneticVariation BEFREE To clarify the characteristics of lymphoproliferative disorder (LPD) in patients with RA treated with MTX. 28165538

2017
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE Other covariates included patient characteristics (age, gender, race, smoking status, education, BMI, modified CharlsonDeyo comorbidity index), CV characteristics (hypertension, diabetes, alcohol abuse), pharmacologic exposures (MTX, anti-TNF, glucocorticoids) and RA severity/activity markers (RA disease duration, mean DAS, CRP, RF positivity, anti-CCP positivity). 24489016

2014
Entrez Id: 4580
Gene Symbol: MTX1
MTX1
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.080 Biomarker BEFREE Cohort 2: 64 MTX-resistant established RA patients [144 (107) months] who started infliximab therapy. 21134963

2011