Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 Biomarker BEFREE Regression analysis revealed that pre-treatment levels of miR-199a-5p and miR-221-3p could help to predict platelet response to TPO-RA-treatment. 30885035

2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 Biomarker BEFREE Higher levels of ICAM-1, thrombomodulin, and H3Cit-DNA were found in ITP patients, both before and after TPO-RA-treatment, compared with controls. 31805421

2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 Biomarker BEFREE MV-associated TF-activity was low in controls and in ITP patients before and after initiation of TPO-RA-treatment. 31280643

2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 AlteredExpression BEFREE Immunomodulation was assessed by measuring serum IgG anti-platelet antibody levels; TPO-RA-treated mice had significantly reduced IgG anti-platelet antibodies despite the increasing platelet counts. 31146647

2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 GeneticVariation BEFREE Previous long-term TPO-RA clinical trials have shown that thrombotic events occurred in 6% of TPO-RA-treated ITP patients. 29215956

2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.060 AlteredExpression BEFREE There was no significant difference in TGF-β1 levels between TPO-RA-treated ITP patients and HCs. 28142109

2017