|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
The data on cytogenetic aberrations (11q22, 13q14, trisomy 12) and IGHV mutation status were also considered in PFS analyses.
|
31054420 |
2019 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Cases with mutated and unmutated IGHV status showed increased CA and MN frequencies compared to controls (P ≤ 0.0007), but no differences between both groups were found.
|
31037299 |
2019 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
Prognostic factors such as chromosome abnormalities (trisomy 12, 11q deletions and 17p deletions), β2 microglobulin, thymidine kinase, CD38 and ZAP-70 expression, IGHV mutation status, and mutations in genes such as NOTCH1, MYD88, SF3B1, and ATM are also predictors of prognosis.
|
27742074 |
2016 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
In the overall patient population, prognostic parameters such as IGHV gene mutational status (P < .0001), CD38 expression (P < .0001), 70-kDa zeta-associated protein (ZAP-70) expression (P < .0001), and cytogenetic abnormalities (P = .01) predicted for TTFT on univariate analysis.
|
25445470 |
2015 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
Differences related to the expression of 25 miRNAs were found to be independent from IGHV mutation status or cytogenetic aberrations.
|
24916701 |
2014 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
A significantly lower expression of LAIR1 was observed in patients with Binet stage B or C disease (P=0.023), and in the presence of high-risk cytogenetic abnormalities (P=0.048) or unmutated immunoglobulin heavy chain variable region genes (P<0.0001).
|
24415628 |
2014 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
IGHV-mutated cases were significantly more frequent among cMBLs (P = 0.005), whereas the distribution of CD38 and ZAP-70 positive cases, of patients with NOTCH1 and SF3B1 mutations or exhibiting the major CLL cytogenetic abnormalities, was similar in the two groups.
|
24036852 |
2013 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
Telomere length/telomerase level profiles identified subgroups of patients with different clinical outcomes (P < 0.0001), even within the subsets of chronic lymphocytic leukemia defined by IGVH mutational status or chromosomal aberrations.
|
21933855 |
2012 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
The expression of ZAP-70 mRNA was significantly associated with Binet stage (P < 0.001), lactate dehydrogenase (P = 0.003), ZAP-70 protein (P = 0.018), IGHV mutational status (P = 0.038), and cytogenetic abnormality of del(17p13) or del(11q22.3) (P = 0.037) in CLL patients.
|
22362302 |
2012 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
In our cohort of 104 untreated patients carrying +12, NOTCH1 mutations occurred in 24% of cases and were associated to unmutated IGHV genes (P=0.003) and +12 as a sole cytogenetic abnormality (P=0.008).
|
22207691 |
2012 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Multivariable models of PFS and OS showed that immunoglobulin heavy chain variable region mutational status was significant for both, whereas cytogenetic abnormalities were significant only for OS.
|
21321292 |
2011 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
On pooled multivariable analysis of patients in both cohorts adjusting for age, sex, Rai stage, CD38 status, ZAP-70 status, immunoglobulin heavy chain variable (IGHV) gene mutation status, CD49d status, and cytogenetic abnormalities assessed by interphase fluorescent in situ hybridization testing, 25(OH)D insufficiency remained an independent predictor of TTT (HR = 1.47; P = .008), although the association with OS was not significant (HR = 1.47; P = .07).
|
21048153 |
2011 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
Clinical features and molecular/biologic factors such as ZAP-70, immunoglobulin heavy chain (IGHV) gene mutation status, and cytogenetic abnormalities on fluorescent in situ hybridization (FISH) have been found to be robust predictors of treatment-free survival and overall survival among newly diagnosed patients.
|
20008228 |
2009 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
We tested the efficacy and safety of oral fludarabine and cyclophosphamide as front-line therapy in chronic lymphocytic leukemia (CLL) and assessed the influence of immunoglobulin variable region heavy chain (IgVH) gene mutation status, interphase cytogenetic abnormalities, and expression of ZAP-70 and CD38 on clinical outcome.
|
18587576 |
2008 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
AlteredExpression |
BEFREE |
This new technique provides highly reliable results well correlated with the mutational status of IgVH genes, CD38 expression, Binet stage and cytogenetic abnormalities.
|
18223290 |
2008 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated its relevance as independent prognosticator for overall survival and time to treatment (TTT) in a series of 303 (232 for TTT) CLLs, in comparison with other biologic or clinical prognosticators (CD38, ZAP-70, immunoglobulin variable heavy chain (IGHV) gene status, cytogenetic abnormalities, soluble CD23, beta2-microglobulin, Rai staging).
|
17959854 |
2008 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Probes for 13q14 (D13S319), 17p13 (p53), the centromere of chromosome 12 (CEP12), and 14q32 (IGHC/IGHV) were applied to detect chromosomal aberrations in peripheral blood samples from 83 B-CLL patients (60 men, 23 women).
|
17562621 |
2007 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
MDR-1, but not MDR-3 gene expression, is associated with unmutated IgVH genes and poor prognosis chromosomal aberrations in chronic lymphocytic leukemia.
|
17107902 |
2006 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
GeneticVariation |
BEFREE |
A strong overall correlation existed between the presence of different chromosome abnormalities and a number of prognostic factors including immunoglobulin heavy chain variable region mutation status (P = 0.011), time to treatment (P = 0.025) and lymphocyte doubling time (P = 0.034).
|
15686453 |
2005 |
|
LOC102724971
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia.
|
14961036 |
2004 |