|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The tumor is thought to be histogenetically less associated with HPV infection, and its teratomatous components with an absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) suggest a analogous histogenesis compared to pure mature or immature teratoma.
|
31684979 |
2019 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
A virtually universal chromosomal anomaly in GCTs is increase in 12p copy number, often in the form of isochromosome 12p [i(12p)], but this aspect of sarcomatoid YSTs has not hitherto been studied.
|
31478941 |
2019 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) in mature ovarian teratomas suggests that they may be analogous to prepubertal testicular teratomas, but there are no data regarding genetic changes in the teratomatous components of ovarian mixed GCTs.
|
16547466 |
2006 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The characteristic chromosome abnormality associated with PKS is i(12p), which is seen predominantly in skin fibroblast cultures.
|
14641998 |
2003 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The amplification of the short arm of the chromosome 12, especially as the i(12p) marker chromosome, has been found to be a highly nonrandom chromosome abnormality associated with testicular germ cell tumors (TGCT).
|
12034520 |
2002 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Most adult testicular germ cell tumors have a characteristic chromosomal abnormality that is an isochromosome 12p [i(12p)].
|
12072204 |
2002 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
No losses were found on 12q and 17p despite the fact that the most common cytogenetic abnormality in TGCTs is an i(12p) and that the TP53 gene on 17p is the most frequently mutated gene in human cancers.
|
7547632 |
1995 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
We confirmed that an isochromosome for 12p, i(12p), is the only consistent structural chromosomal abnormality in TGCT, present in about 70% of our cases.
|
8527395 |
1995 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
i(12p) is a highly nonrandom chromosomal marker seen in about 80% of male germ cell tumors with evaluable cytogenetic abnormalities.
|
8308927 |
1994 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Although recent cytogenetic analyses of GCTs have defined nonrandom chromosome abnormalities in these tumors, no attempt has so far been made to compare i(12p)-positive and -negative tumors in terms of their cytogenetic, histologic, and clinical features.
|
7512366 |
1993 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
In the remaining so-called i(12p)-negative tumours other cytogenetic abnormalities can be found.
|
8097468 |
1993 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The i(12p) marker chromosome has been found to be a highly nonrandom chromosome abnormality associated with germ cell tumors (GCTs).
|
1384658 |
1992 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Cytogenetic analysis of germ cell tumors (GCTs) has identified i(12p) as a specific cytogenetic abnormality identified in more than 80% of GCTs, present in all histologies, in primary and metastatic lesions, in testicular and extragonadal presentations, and in ovarian and sex cord stromal tumors.
|
1663944 |
1991 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
Thus, our study extends to cell lines the observation from fresh tumor tissues that i(12p) is a highly nonrandom chromosomal abnormality of testicular GCT.
|
2253191 |
1990 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
The only structural chromosomal abnormality in common was an i(12p).
|
2846145 |
1988 |
|
IGHV1-12
|
Congenital chromosomal disease
|
0.100 |
Biomarker |
BEFREE |
This finding confirms the reports that the i(12p) isochromosome is a specific chromosomal abnormality in cases of malignant testicular tumors.
|
6708198 |
1984 |