Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 Biomarker BEFREE Biomarker levels were analyzed in plasma samples from healthy individuals, individuals with adenomas, CRC patients, and patients with non-cancer diseases and we identified one protein, tropomyosin 3 (Tpm3) that could discriminate CRC at a significant level (<i>p</i> = 0.0146). 31810358

2019
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 AlteredExpression BEFREE Tropomyosin-related kinase A (TRKA) fusion was originally detected in colorectal carcinoma that had resulted in expression of the oncogenic chimeric protein TPM3-TRKA. 29360440

2018
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 Biomarker BEFREE Entrectinib is currently showing great promise in phase I/II clinical trials, including the first documented objective responses to a TRK inhibitor in colorectal carcinoma and in NSCLC. 26939704

2016
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 Biomarker BEFREE Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer. 26546295

2016
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 Biomarker BEFREE The TPM3-NTRK1 rearrangement is a recurring event in CRC that renders tumors sensitive to TRKA kinase inhibitors in preclinical models. 26563355

2016
Entrez Id: 7170
Gene Symbol: TPM3
TPM3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 GeneticVariation BEFREE NGS was performed on the 3 IHC positive cases and confirmed TPM3-NTRK1 rearrangements in the two CRC cases. 26472021

2015