Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression BEFREE This study suggests that activation of Slit2/Robo1 signaling in CRC induces tumor metastasis partially through activation of the TGF-β/Smads pathway. 31242633

2019

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker BEFREE These findings suggest that AK3 and SLIT2 may be potential candidates involved in genetic susceptibility to CRC. 27888432

2017

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression BEFREE The SLIT2 and SLIT3 promoters are hypermethylated in CRC cell lines. miR-218 and SLIT2 expressions correlated positively. 27462788

2016

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker BEFREE Here, we employed several complementary mouse models of intestinal cancers, including the Slit2 transgenic mice, the ApcMin/+ spontaneous intestinal adenoma mouse model, and the DMH/DSS-induced colorectal carcinoma model to clarify function of Slit2/Robo1 signaling in intestinal tumorigenesis. 25605242

2015

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker BEFREE Robo-interacting ubiquitin-specific protease 33 (USP33) is required for the inhibitory function of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1. 25242263

2015

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression BEFREE The expression levels of miR-218, SLIT2 and SLIT3 in CRC tissues were decreased than those in adjacent normal tissues (all P < 0.05). miR-218 expression was significantly associated with TNM stage, lymph node metastasis (LNM) and differentiation (all P < 0.05). 24294377

2013

Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 PosttranslationalModification BEFREE SLIT2 promoter region methylation was found in 23 (72%) of 32 primary colorectal cancers. 12615722

2003