|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
Biomarker |
BEFREE |
Elevated citrullination of ADAMTS13 was observed in plasma samples of patients with sepsis or noninfected patients who were elderly (eg, age >65 years) and had underlying comorbidities (eg, diabetes mellitus and hypertension) as compared with healthy donors.
|
31248335 |
2019 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
GeneticVariation |
BEFREE |
Eighty-seven DM and 84 control individuals were recruited. vWF and ADAMTS13 activities as well as vWF antigen were measured by collagen-binding assay (CBA), residual-CBA, and in-house enzyme-linked immunosorbent assay, respectively.
|
30181741 |
2018 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
Biomarker |
BEFREE |
In conclusion, the deficiency of ADAMTS13 may underlie the onset of lethal arrhythmias in diabetes through increased CaMKII phosphorylation in cardiomyocytes.
|
29976618 |
2018 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
GeneticVariation |
BEFREE |
In contrast, low ADAMTS13 was associated with increased risk of dementia throughout follow-up (hazard ratio per SD decrease- 1.16 [1.06-1.28]), which alike for ischaemic stroke, was modified by the presence of diabetes (P-interaction = 0.003).
|
29615758 |
2018 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
Biomarker |
BEFREE |
Regarding endovascular therapies, a reduced ADAMTS13 concentration (<982 ng/mL) was an independent predictor of futile recanalization (odds ratio = 67.4 [1.4-3,282.1], <i>p</i> = 0.034), together with age and diabetes mellitus.
|
29444972 |
2018 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
GeneticVariation |
BEFREE |
Genetically predicted ADAMTS-13 activity, based on three genetic variants, was consistently inversely associated with IHD (IVW odds ratio [OR] 0.91 per effect size; 95% confidence interval [CI] 0.86-0.97) but not with diabetes (OR 0.94, 95% CI 0.88-1.01) or high or low-density lipoprotein cholesterol (0.01, 95% CI -0.02 to 0.04; -0.01, 95% CI -0.04 to 0.02, respectively).
|
30099840 |
2018 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
AlteredExpression |
BEFREE |
Although ADAMTS13 activity was positively associated with fasting glucose and insulin, the association with incident diabetes did not change when we adjusted for these covariates.
|
27787621 |
2017 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
GeneticVariation |
BEFREE |
Alteration in ADAMTS13-VWF balance may be one of the key pathophysiological mechanisms of thrombotic angiopathy in diabetes mellitus.
|
28495930 |
2017 |
|
ADAMTS13
|
Diabetes Mellitus
|
0.090 |
Biomarker |
BEFREE |
Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis.
|
28634421 |
2017 |