Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 GeneticVariation BEFREE TMZ treatment ameliorated diabetes-associated structural and functional alterations by inhibiting Nox2 and TRPC3 without having any effects on glucose, insulin and AGEs levels. 30962089

2019
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 AlteredExpression BEFREE The multicomponent cytosolic Nox2 has an obligatory component, Ras-related C3 botulinum toxin substrate 1 (Rac1); in diabetes, Rac1 is functionally and transcriptionally active. 30347077

2018
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 Biomarker BEFREE Blockade of NOX2 or arginase represents a strategy to prevent diabetes-induced premature EC senescence by preserving NO bioavailability. 28617308

2017
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 AlteredExpression BEFREE LV NADPH oxidase (Nox2 gene expression and activity, and lucigenin-enhanced chemiluminescence), as well as oxidative stress, were increased by diabetes, exaggerated in diabetic dnPI3K mice, and attenuated by CoQ(10). 25937176

2015
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 Biomarker BEFREE Myocardial mRNA levels of interleukin-6, tumor necrosis factor-α, plasminogen activator inhibitor-1, angiotensin type 1 receptor, angiotensinogen, NADPH oxidase subunits (p47(phox), gp91(phox)), glutathione peroxidase-3. and connective tissue growth factor were increased in CRP/DM compared with Wt/DM. 21519150

2011
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.360 Biomarker BEFREE Diabetes was induced with streptozotocin in wild-type mice or NOX2 knockout mice. 18806296

2009