Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.350 Biomarker BEFREE Therefore, PXR and CAR may become new therapeutic targets for metabolic syndrome, including obesity and diabetes. 30227815

2019

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.350 Biomarker BEFREE Increasing evidences have suggested that PPAR, FXR, LXR ,PXR and CAR are involved in the development of diabetes and its complications through different mechanisms, including the regulation of glucose and lipid metabolism, insulin and inflammation response and related others. 29886826

2019

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.350 Biomarker BEFREE As a key regulator of metabolism and inflammation, the orphan nuclear hormone receptor, liver receptor homolog-1 (LRH-1), has potential as a therapeutic target for diabetes, nonalcoholic fatty liver disease, and inflammatory bowel diseases (IBD). 31419141

2019

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.350 Biomarker BEFREE Dietary polyphenol EGCG could serve as a promising PXR/CAR activator and therapeutic intervention in diabetes. 30183039

2018

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.350 Biomarker BEFREE The nuclear protein constitutive active/androstane receptor (CAR or NR1I3) regulates several liver functions such as drug and energy metabolism and cell growth or death, which are often involved in the development of diseases such as diabetes and hepatocellular carcinoma. 29133527

2018