|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Whether PEDF is increased or decreased in diabetic retinopathy has been controversial but we observed lower PEDF in the ROP samples than in the controls.
|
28502635 |
2017 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
AlteredExpression |
BEFREE |
Furthermore, we pursue the causal relationship between LOX-NOX system and regulation of PEDF expression during DR. For these purposes, we used an experimental eye model in which normal mice were injected intravitreally with 12-HETE with/without PEDF.
|
25562624 |
2015 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
AlteredExpression |
BEFREE |
These results demonstrate long-term efficacy of AAV-mediated PEDF overexpression in counteracting retinal neovascularization in a relevant animal model, and provides evidence towards the use of this strategy to treat angiogenesis in DR and other chronic proliferative retinal disorders.
|
22911805 |
2012 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
These results suggest that PEDF is an endogenous antagonist of LRP6, and blocking Wnt signaling may represent a novel mechanism for its protective effects against diabetic retinopathy.
|
21576363 |
2011 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
The PEDF-Tg mice provide a useful model for studying the roles of angiogenic inhibitors in neovascular disorders such as diabetic retinopathy.
|
21281801 |
2011 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
AlteredExpression |
BEFREE |
Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy.
|
20219495 |
2010 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation |
BEFREE |
Our results suggest lack of association of PRKCB1 gene promoter polymorphisms and moderate protective association of PEDF gene polymorphism with DR in the south Indian population.
|
20141354 |
2010 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation |
BEFREE |
In addition, two other PEDF gene polymorphisms, -5736T>C (rs12150053) and -5304C>T (rs12948385), have been associated with increased risk of diabetic retinopathy, but have not yet been studied among patients with exudative AMD.
|
19223990 |
2009 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
PEDF was determined in surgically excised retinal tissue originating from patients with ischemic diabetic retinopathy and in primary guinea pig Müller cell cultures exposed to the protein synthesis inhibitor cycloheximide (CHX) and to hypoxia.
|
18676622 |
2008 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR.
|
17658465 |
2007 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Recently, pigment-epithelium-derived factor (PEDF) has also been shown to play a role in diabetic retinopathy.
|
17284935 |
2007 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy.
|
17653050 |
2007 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.
|
16901919 |
2006 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy.
|
16707486 |
2006 |
|
SERPINF1
|
Diabetic Retinopathy
|
0.300 |
Biomarker |
BEFREE |
Since sympathetic nerves are damaged in diabetes and PEDF appears to be regulated by beta-adrenergic receptors, these results suggest a role for sympathetic nerves in diabetic retinopathy.
|
15961351 |
2005 |