Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE Tumor-treating fields induce autophagy by blocking the Akt2/miR29b axis in glioblastoma cells. 31375748

2019
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE We hypothesized that miR-641 regulates its host AKT2 and that this regulation may become dysfunctional in glioblastoma. 28576488

2017
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 AlteredExpression BEFREE There is a direct relationship between human GBM patient outcome and both AKT1 and AKT2 mRNA levels, but an inverse relationship with AKT3 mRNA. 27422127

2016
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE Moreover, AKT2 is also exclusively required for the maintenance and survival of other PTEN-deficient solid tumors, including breast cancer and glioblastoma. 24838891

2014
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE In this study, the human glioblastoma cell line U87 was stably transfected with a lentivirus vector expressing a short hairpin RNA (shRNA) targeting AKT2. 22771706

2012
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE Amplifications encompassing AKT2 (19q13.2) or CCNE1 (19q12) were identified in some glioblastomas. 20164239

2010
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 AlteredExpression BEFREE Additionally, immunohistochemical analysis showed that Akt2 expression positively correlates with Fn14 expression in glioblastoma multiforme specimens. 19861406

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE In vivo PTD-DRBD delivery of EGFR and Akt2 siRNAs induced tumor specific apoptosis and significantly increased survival in intracerebral glioblastoma mouse models (p < 0.0005), whereas delivery of irrelevant control siRNAs did not alter longevity. 19901546

2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker BEFREE Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. 15782140

2005
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 AlteredExpression BEFREE Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. 9799739

1998