Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression BEFREE Yet, there is little contemporary data on the differential expression of TGF-β isoforms at the mRNA and protein level or TGF-β/Smad pathway activity in glioblastomas in vivo.Here we studied 64 newly diagnosed and 16 recurrent glioblastomas for the expression of TGF-β1-3, platelet-derived growth factor (PDGF)-B, and plasminogen activator inhibitor (PAI)-1 mRNA by RT-PCR and for the levels of TGF-β1-3 protein, phosphorylated Smad2 (pSmad2), pSmad1/5/8 and PAI-1 by immunohistochemistry.Among the TGF-β isoforms, TGF-β1 mRNA was the most, whereas TGF-β3 mRNA was the least abundant. 25849941

2015
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker BEFREE Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. 20716639

2010
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression BEFREE Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways. 20467333

2010
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker BEFREE Bacterial O6-methylguanine-DNA methyltransferase reduces N-methyl-N'-nitro-N-nitrosoguanidine induction of plasminogen activator in Mer- human glioblastoma A1235 cell line. 9678063

1998
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker BEFREE Transforming growth factor-beta 1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines. 3262361

1988
Entrez Id: 5340
Gene Symbol: PLG
PLG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker BEFREE Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain. 3697974

1986