Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 Biomarker BEFREE GPR110 is a member of the adhesion G protein-coupled receptor family, which has been identified as an oncogene in various cancers, including hepatocellular carcinoma, lung cancer, prostatic cancer and glioma. 30638950

2019
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 AlteredExpression BEFREE FOXC1 decreased BTB permeability by increasing the promoter activity and expression of ZO-1 and occludin, and promoted glioma angiogenesis by increasing the promoter activity and expression of chemokine (C-X-C motif) receptor 7b (CXCR7). 28287613

2017
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 Biomarker BEFREE CXCR7 actively promotes the proliferation and invasive behavior of glioma tumor cells and stem-like progenitor cells and may be a potential target for glioma therapy. 25550535

2015
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 AlteredExpression BEFREE We immunohistochemically studied the expression of CXCR7 and its ligand SDF1α in a cohort of 354 human patients with glioma. 26109200

2015
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 AlteredExpression BEFREE Likewise, pertussis toxin abolished SDF-1-induced activation of Erk and Akt in CXCR7-only expressing human glioma cell lines. 22083878

2012
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
CUI: C0017638
Disease: Glioma
Glioma 		0.060 Biomarker BEFREE Therapeutic targeting of g-protein coupled receptor-mediated epidermal growth factor receptor transactivation in human glioma brain tumors. 18991757

2008