|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Leukemia fusion gene analysis demonstrated positive EVI1 and negative IgH and TCR gene rearrangement.
|
30608452 |
2019 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development.
|
25388957 |
2015 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
AlteredExpression |
BEFREE |
One is based on the detection of aberrant expression of leukemia specific antigens by flow cytometry and the other one uses the specific rearrangements of the TCR or Ig genes, which can be detected by quantitative PCR in the DNA of leukemic cells.
|
23233572 |
2012 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Our findings clearly limit the use of HMMR-TCR therapy to MHC- mismatched HSC transplantation, in which HLA-A2 differences can be used to restrict recognition to patient HSCs and leukemia.
|
22371883 |
2012 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
On the basis of previous analyses of T-cell receptor (TCR) gene rearrangement patterns, we hypothesized that some late recurrences of T-ALL might in fact represent second leukemias.
|
21357790 |
2011 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
In 3 of 15 patients, the leukemia and histiocytic lesion shared immunoglobulin H or monoclonal TCR gene rearrangements and, in 4 of 15 patients, clonal identity was documented by fluorescence in situ hybridization.
|
19642834 |
2010 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
TCR-Vbeta flow cytometric analysis of peripheral blood for assessing clonality and disease burden in patients with T cell large granular lymphocyte leukaemia.
|
20154036 |
2010 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
Although quantitative detection of clonal immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements is currently considered to be the standard method, leukaemia fusion genes provide other possible targets for MRD follow-up, as already demonstrated in TEL/AML1-positive ALLs.
|
19158828 |
2009 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Pre-TCR signaling synergizes with TEL-JAK2 to transform immature thymocytes and initiate leukemogenesis as shown by (1) the delayed leukemia onset in Rag2-, CD3epsilon- and pTalpha-deficient mice, (2) the occurrence of recurrent chromosomal alterations in pre-TCR-deficient leukemia, and (3) the correction of delayed leukemia onset in Rag2-deficient TEL-JAK2 mice by an H-Y TCRalphabeta transgene that mimics pre-TCR signaling.
|
17192390 |
2007 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
In conclusion, PCR amplification of segments of rearranged TCR-beta is reliable and highly suitable for the detection of small populations of clonal T-cells in asymptomatic HTLV-I carriers who present abnormal peripheral blood lymphocytes providing an additional instrument for following up these patients with potentially higher risk of leukemia.
|
15917950 |
2005 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
The data suggest that adoptive immunotherapy with WT1-TCR gene-modified patient T cells should be considered for the treatment of leukemia.
|
16020516 |
2005 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
Utilizing newborn screening ('Guthrie') cards, leukemic clones have been detected retrospectively in dried blood spots using two different PCR-based approaches: (i) the amplification of patient/leukemia-specific breakpoint fusion sequences of rearranged oncogenes; and (ii) the amplification of clonal immunoglobulin heavy chain gene (IgH) or T cell receptor (TcR) gene rearrangements.
|
15061193 |
2004 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Detection of a clonal T cell receptor (TCR) gene rearrangement is used in the diagnosis of primary cutaneous T cell lymphomas (CTCL) whereas chromosomal aberrations serve as a diagnostic tool for leukaemias and nodal lymphomas.
|
15086537 |
2004 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia.
|
12393705 |
2003 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
Heteroduplex analysis with standardized DHPLC conditions simplifies the detection of unknown clonal or polyclonal TCR rearrangements in newly diagnosed leukemias.
|
11673369 |
2001 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Heterogeneous TCR delta Vdelta2-Ddelta3 rearrangements and their relation to IgH and TCR gamma gene status in childhood B cell precursor leukaemias.
|
10613353 |
1999 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
Several means of analyzing minimal residual disease (MRD) in leukemia involving the rearranged T cell receptor (TCR) gene have been described.
|
9111164 |
1997 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Southern analysis and polymerase chain reaction (PCR) were used to detect the rearranged V-D-J segment of T-cell receptor delta (TCR delta) gene from malignant cell specimens of patients with leukemia and lymphoma of T-cell lineage.
|
9209365 |
1997 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Leukaemia is a monoclonal disease which frequently displays clonal rearrangement of the T-cell receptor gamma (TCR gamma) and/or immunoglobulin heavy chain (IgH) gene.
|
9507369 |
1997 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
Southern analysis and polymerase chain reaction (PCR) were used to detect the rearranged V-D-J segment of T-cell receptor delta (TCR delta) gene from malignant cell specimens of patients with leukemia and lymphoma of T-cell lineage.
|
8756082 |
1996 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
TcR and lg gene rearrangements have been demonstrated in many different hematologic disorders and TcR gene rearrangement has been particularly useful in the diagnosis of patients with CD8 large granular lymphocyte leukemias.
|
8951602 |
1996 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
TCR delta gene recombination patterns were analysed by Southern blot, polymerase chain reaction and nucleotide sequencing in acute myeloid leukaemias, with coexpression of lymphoid antigens (Ly+ AML, n=10) as well as in early T-cell acute lymphoblastic leukaemias with (My+ T-ALL, n=10) and without coexpression of myeloid antigens (My(-) T-ALL, n=9).
|
8616087 |
1996 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
Biomarker |
BEFREE |
These findings suggest that monoclonal proliferation of TCR gamma delta-positive granular lymphocytes (GL) can be associated with PRCA even in a patient having a small proportion of leukemia GL, which we propose to designate as 'smoldering GLL'.
|
7653209 |
1995 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we analysed 49 children with acute leukaemia (29 B-precursor acute lymphoblastic leukaemia (ALL), 5 relapsed cALL, 6 T-ALL, 7 acute non-lymphocytic (ANLL) and 2 mixed lineage leukaemias), for the presence of different immune system gene rearrangements (Ig JH, C kappa, C lambda, TCR J gamma, C beta, J delta and J alpha) by Southern blot hybridisation.
|
7786608 |
1995 |
|
TRBV20OR9-2
|
leukemia
|
0.100 |
AlteredExpression |
BEFREE |
TCR-beta chain gene rearrangement and expression in human T-cell development and in leukemia.
|
8207984 |
1994 |