Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10923
Gene Symbol: SUB1
SUB1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.050 Biomarker BEFREE Aberrant methylation in the sample of patients with CLL was shown for secreted frizzled-related protein 1 (68.8%), secreted frizzled-related protein 2 (65.6%), death-associated protein kinase 1 (50.0%), E-cadherin (21.9%), secreted frizzled-related protein 4 (15.6%), p15 (9.4%), p16 (6.3%), retinoic acid receptor beta2 (3.1%), secreted frizzled-related protein 5 (3.1%) and tissue inhibitor of matrix metalloproteinases 3 (3.1%). 19347729

2009
Entrez Id: 10923
Gene Symbol: SUB1
SUB1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.050 PosttranslationalModification BEFREE Our results suggest that methylation of the p15 gene promoter can be detected in a small subset of B-CLL patients, at all stages of the disease. 17546638

2007
Entrez Id: 10923
Gene Symbol: SUB1
SUB1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.050 PosttranslationalModification BEFREE In all, 5 (8.9%) CLL samples harboured concurrent methylation of both p15 and p16. 16565223

2006
Entrez Id: 10923
Gene Symbol: SUB1
SUB1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.050 Biomarker BEFREE DAP kinase was methylated in 18 (36%) patients while p14 and Apaf-1 were completely unmethylated in all the primary CLL samples. 16897188

2006
Entrez Id: 10923
Gene Symbol: SUB1
SUB1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.050 GeneticVariation BEFREE Several cases of CLL manifested LOH at a locus telomeric to the p15 and p16 tumor suppressor genes, all being early to intermediate stage disease. 9018124

1997