Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0023518
Disease: Leukocytosis
Leukocytosis 		0.030 Biomarker BEFREE Other cytokine-phenotype associations included increased IL-8 and constitutional symptoms; IL-2R, IL-12, and transfusion need; IL-2R, IL-8, and leukocytosis; IP-10 and thrombocytopenia; HGF, MIG, IL-1RA, and marked splenomegaly; and IL-1RA, IL-2R, IP-10, MIP-1β, and JAK2V617F. 21300928

2011
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0023518
Disease: Leukocytosis
Leukocytosis 		0.030 Biomarker BEFREE These data suggest that IL-1 and TNF-alpha induce astrocytes to produce IL-8 and MCAF transcriptionally and post-transcriptionally, both of which may be responsible for leucocytosis seen in inflammation of the CNS. 1937574

1991