|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Usefulness of IGH/TCR PCR studies in lymphoproliferative disorders with inconclusive clonality by flow cytometry.
|
23943305 |
2014 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
FcRγ(+) DN T cells also showed enhanced sensitivity to TCR restimulation-induced cell death (RICD) despite lacking Fas, suggesting that TCR stimulation of autoreactive T cells in vivo may serve to eliminate FcRγ(+) T cells and thus exert partial control over lymphoproliferative disease.
|
23313147 |
2013 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
The assessment of the presence of clonal lymphoproliferations via polymerase chain reaction (PCR)-based analysis of rearranged immunoglobulin (Ig) or T-cell receptor (TCR) genes is a valuable technique in the diagnosis of suspect lymphoproliferative disorders.
|
23296958 |
2013 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Polymerase chain reaction analysis of TCR-γR is a useful method for distinguishing different clonal processes and is recommended when differentiation of primary and secondary lymphoproliferative disorders is required.
|
21844453 |
2011 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
TCR gene rearrangement is important in the diagnosis of clonality and used as markers to detect minimal residual disease in lymphoproliferative disorders.
|
21114900 |
2010 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Analysis of Ig/TCR genomic V(D)J repertoires by PCR based lymphoid clonality analysis within a diagnostic setting allows distinction of clonal from reactive lymphoproliferative disorders, clonal tracking for evidence of tumor dissemination and follow-up, identification of a lymphoid origin in undiagnosed tumors and evaluation of clonal evolution.
|
19731811 |
2009 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
Clinical follow-up was available for 5 of 7 TUGSE cases with clonal TCR gene rearrangement for an average period of 1.75 years after the initial biopsy or excision, and there was no evidence of local recurrence or development of systemic T-cell lymphoproliferative disorder.
|
19846813 |
2009 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
TCR alpha beta+/CD4+ T-large granular lymphocyte (LGL) lymphocytosis is a subgroup of monoclonal T-LGL lymphoproliferative disorders that are different from the CD8+ TCR alpha beta T-LGL.
|
18361934 |
2008 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
This study summarizes the outcomes of PCR analysis of IgH and TCR gene rearrangements in 91 bioptic cases of lymphoproliferative disorders.
|
18190238 |
2008 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
This report highlights the importance of TCR gene rearrangement analysis in the diagnosis of unusual gastric inflammation, and the use of capillary electrophoresis based polymerase chain reaction in the follow up of lymphoproliferative disorders.
|
15509690 |
2004 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Sixty cases with a confirmed histological diagnosis of a T-cell lymphoproliferative disorder and TCR gamma GR were identified in our lymphoma registry from 1995 to 2001.
|
12707372 |
2003 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
Fourth, other lymphoproliferative disorders that are associated with CTCL share the same TCR gene rearrangements and therefore arise as subclones of the original tumor.
|
11594579 |
2001 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
However, in approximately one third of the cases of this lymphoproliferative disease rearrangements of T-cell receptor (TCR) genes indicating clonal expansion of T cells are not detectable.
|
11337383 |
2001 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
Polymerase chain reaction amplification of DNA for T-cell receptor (TCR) gene rearrangement analysis is helpful in the evaluation of T-cell lymphoproliferative disorders.
|
11175635 |
2001 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Therefore, rearrangement of the Ig, T-cell receptor (TCR) genes, and surface markers are generally considered as useful markers of the B- and T-cell lineage in lymphoproliferative disorders.
|
10905058 |
2000 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
We conclude that nonradioactive PCR-SSCP for TCR-gamma gene rearrangement analysis is a useful adjunct to routine histological and immunophenotypic methods in the diagnosis of T-cell lymphoproliferative disorders in paraffin-embedded tissue.
|
9916920 |
1999 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
We have identified a YAC encompassing 70% of the TCR alpha/delta locus, which has been used as a fluorescence in situ hybridization probe to detect chromosome rearrangements involving 14q11, both at metaphase and within interphase nuclei, in patients with a variety of T-lymphoproliferative disorders.
|
9242557 |
1997 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
Clinical utility of heteroduplex analysis of TCR gamma gene rearrangements in the diagnosis of T-cell lymphoproliferative disorders.
|
9291458 |
1997 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
GeneticVariation |
BEFREE |
The analysis of the configuration of the immunoglobulin (Ig) and T-cell receptor (TCR) gene regions has been of great relevance in defining conclusively the nature of several lymphoproliferative disorders in man.
|
1890861 |
1991 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
We also examined briefly the participation of immunoglobulin and TCR genes in chromosomal aberrations present in many lymphoproliferative disorders, often involving protooncogenes and potentially of tumorigenic consequences.
|
2247756 |
1990 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
Rearrangement of the immunoglobulin (Ig) and T-cell receptor (TcR) genes generally has been considered a useful marker of B- and T-cell lineage in lymphoproliferative disorders.
|
2331523 |
1990 |
|
TRBV20OR9-2
|
Lymphoproliferative Disorders
|
0.100 |
Biomarker |
BEFREE |
We have studied the arrangement of the alpha, beta and gamma T cell receptor (TCR) genes in 27 patients with T cell lymphoproliferative disorders.
|
2961364 |
1987 |